Osteoporosis prevention and treatment. Pharmacological management and treatment implications

Drugs & Aging
S K Sankaran

Abstract

In the current economic climate, osteoporosis is a major public health issue because of the high rate of fractures associated with the disease. Prevention of osteoporosis is a cost-effective approach, especially in aging populations. Encouraging moderate exercise and dietary supplementation with calcium and vitamin D, especially in institutionalised elderly people, are the major nonpharmacological management measures used to prevent and treat osteoporosis. Pharmacological measures have been developed in the last few years and extensive research is under way. Hormone replacement therapy results in increased bone mass, especially in postmenopausal patients, and its effect is currently being investigated in the elderly population. The bisphosphonates, especially alendronate, are promising and have few adverse effects, but the issue of cost needs to be addressed. Pharmacological agents that stimulate bone formation, such as sodium fluoride, growth hormone and other trophic factors, are being researched.

Citations

Sep 1, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I-Ju ChenLian-Hua Huang
Mar 18, 2000·Archives of Physical Medicine and Rehabilitation·P A LimT H Oh
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K S LeungL Qin
Jul 31, 1998·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·C J MooneyC R Kessenich
Jan 13, 2001·Dermatologic Clinics·L C Williams, L T Nesbitt
Jul 12, 2005·Clinics in Sports Medicine·Michael Brunet
Jun 16, 1999·The Annals of Pharmacotherapy·M F Beauchesne, P F Miller

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