Osteoprotegerin/RANK/RANKL axis in cardiac remodeling due to immuno-inflammatory myocardial disease

Experimental and Molecular Pathology
Wei LiuManling Ma

Abstract

Osteoprotegerin (OPG) and the receptor activator of nuclear factor-kappaB ligand (RANKL) are inflammatory cytokines traditionally linked to the regulation of bone remodeling. We hypothesize that the OPG/RANK/RANKL axis may be involved in extracellular matrix remodeling in immuno-inflammatory heart diseases, and explore the probable underlying mechanisms by using anti-IL-17 in the model of experimental autoimmune myocarditis. EAM was induced in Lewis rats by injection of porcine cardiac myosin. All the rats were randomly distributed into day 0, day 7, day 14 and day 28 groups, which means rats in certain group were cervical dislocated on day 0, day 7, day 14 and day 28 respectively. HE staining and Masson's staining were used for measurement of cardiac hypertrophy and interstitial fibrosis. Hydroxyproline content and collagen cross-linking were determined in heart section. Anti-IL-17 or control antibody was injected i.p. 2 h before and 3 days and 7 days after the first myosin immunization in EAM model, that is, group anti-IL-17 or group control antibody. IL-17 and OPG/RANK/RANKL axis expressions were detected by realtime RT-PCR in all the six groups. In the in vitro studies, cardiac fibroblasts were cultured and treated with IL-...Continue Reading

References

Jun 1, 1989·Journal of the American College of Cardiology·K T Weber
Feb 1, 1993·Journal of Molecular and Cellular Cardiology·D Mukherjee, S Sen
Mar 22, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S MinisolaE Romagnoli
Mar 23, 2002·Circulation Research·Francis G Spinale
May 15, 2002·Trends in Cardiovascular Medicine·Jeanine D'Armiento
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Michael SchoppetLorenz C Hofbauer
Oct 11, 2003·Biochemical and Biophysical Research Communications·Y WittrantF Rédini
Jul 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Qianli YuDouglas F Larson
Nov 18, 2005·Biochemical and Biophysical Research Communications·Michael SchoppetBernhard Maisch
Nov 18, 2006·Journal of Thrombosis and Thrombolysis·Prospero B GogoHarold L Dauerman

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Citations

Aug 24, 2011·Circulation. Arrhythmia and Electrophysiology·Angeliki AsimakiJeffrey E Saffitz
Aug 27, 2011·Wiener medizinische Wochenschrift·Daniela-Eugenia MalligaAstrid Fahrleitner-Pammer
Mar 29, 2012·Current Heart Failure Reports·Thor UelandPål Aukrust
Jun 5, 2012·Scandinavian Cardiovascular Journal : SCJ·Zheng-Feng ZhuXiang Wang
Nov 17, 2009·Experimental and Molecular Pathology·Weiwei Feng, Weimin Li
Oct 1, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J BoothD K Bishop
May 8, 2010·Journal of the American College of Cardiology·Shreenidhi M VenurajuAvijit Lahiri
Dec 20, 2011·International Journal of Cardiology·Hailong CaoDongjin Wang
Jan 19, 2013·Cardiology·Shimon Rosenheck
Oct 2, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Anna M JanssonKenneth Caidahl
Sep 16, 2017·Ocular Immunology and Inflammation·Ahmed M Abu El-AsrarGhislain Opdenakker
May 20, 2018·Journal of Cardiovascular Translational Research·Marcello RattazziPaolo Pauletto

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