Osteoprotegrin interacts with biomarkers and cytokines that have roles in osteoporosis, skin fibrosis, and vasculopathy in systemic sclerosis: a potential multifaceted relationship between OPG/RANKL/TRAIL and Wnt inhibitors

Modern Rheumatology
Ali TaylanAli R Sisman

Abstract

We explored the interactions of osteoprotegerin (OPG) with biomarkers of bone turnover and cytokines, including soluble receptor activator for nuclear factor kappa beta ligand (sRANKL), tumor necrosis factor-related apoptosis-induced ligand (TRAIL), and Wnt inhibitors in osteoporosis, vasculopathy and fibrosis related to systemic sclerosis (SSc). The study included 46 SSc patients and 30 healthy controls. Skin thickness, pulmonary fibrosis and/or hypertension, digital ulcers, and calcinosis cutis of SSc patients were assessed. We determined bone mineral density (BMD), and OPG, sRANKL, TRAIL, secreted frizzled-related protein 1 (sFRP-1), Dickkopf-related protein 1 (DKK-1), sclerostin in the serum of both patients and controls. OPG, sclerostin, and sFRP-1 levels were similar between patients and controls (P > 0.05). Femoral neck and lumbar spine BMD and vitamin D levels were lower, and the OC, NTX, sRANKL, DKK1 and TRAIL levels were significantly higher, in patients than in controls (P < 0.05). In subgroup analysis, patients with higher modified Rodnan skin score (mRodnan) had higher DKK-1, sclerostin, and TRAIL levels (P < 0.05); those with diffuse SSc subtype had lower BMD values than those with limited SSc (P < 0.05). Skin and...Continue Reading

References

Oct 10, 2008·The Journal of Rheumatology·Andrea DovioAlberto Angeli
Mar 15, 2012·Nature Communications·Alfiya AkhmetshinaJörg H W Distler
Mar 5, 2013·The Journal of Rheumatology·Addolorata CorradoFrancesco Paolo Cantatore
May 24, 2013·Annals of the Rheumatic Diseases·Clara DeesJörg H W Distler

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Citations

Nov 27, 2019·International Journal of Molecular Sciences·Giovanni AdamiDavide Gatti
Mar 7, 2021·Nutrients·Gaetano IsolaAlberto Lo Gullo
Jun 8, 2021·Frontiers in Endocrinology·Eugenia BertoldoAngelo Fassio
Jun 11, 2021·Advances in Rheumatology·Laiana SchneiderRafael Chakr

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