Osteoradionecrosis of the jaws--a current overview--part 1: Physiopathology and risk and predisposing factors.

Oral and Maxillofacial Surgery
Bruno Ramos ChrcanovicMalcolm Harris

Abstract

The aim of this paper is to explore the current theories about definition, classification, incidence and physiopathology of osteoradionecrosis (ORN) of the jaws. Moreover, it is discussed the predisposing and risk factors for the development of osteoradionecrosis based on the literature review. Osteoradionecrosis is one of the most serious oral complications of head and neck cancer treatment. Osteoradionecrosis is a severe delayed radiation-induced injury, characterised by bone tissue necrosis and failure to heal. Osteoradionecrosis either stabilises or gradually worsens and is notoriously difficult to manage. The most widely accepted theory to explain its cause until recently was the theory of hypoxia, hypovascularity and hypocellularity. A new theory for the pathogenesis of osteoradionecrosis was proposed. The clinical presentations of osteoradionecrosis are pain, drainage and fistulation of the mucosa or skin that is related to exposed bone in an area that has been irradiated. The tumour size and location, radiation dose, local trauma, dental extractions, infection, immune defects and malnutrition can predispose its development. A better understanding of risk factors for the development ORN and of the underlying pathophysiol...Continue Reading

References

Jun 1, 1978·International Journal of Oral Surgery·J Beumer, F A Brady
Nov 1, 1979·Oral Surgery, Oral Medicine, and Oral Pathology·M D RohrerJ V Fayos
May 1, 1979·Head & Neck Surgery·J BeumerR E Harrison
Mar 1, 1979·Head & Neck Surgery·J BeumerR E Harrison
Mar 1, 1975·Archives of Otolaryngology·E G Mainous, G B Hart
Oct 1, 1992·The British Journal of Oral & Maxillofacial Surgery·M Harris
Jul 1, 1992·Head & Neck·J B EpsteinM Lepawsky
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·J JansmaE J Gravenmade
Mar 21, 1992·British Dental Journal·S Meghji
Jun 1, 1990·The British Journal of Oral & Maxillofacial Surgery·I L HutchisonM Harris
Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·R Weiner
Jul 1, 1990·American Journal of Otolaryngology·J BrasJ P van Merkesteyn
Jan 1, 1990·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·R P Berger, J M Symington
Oct 1, 1986·The British Journal of Oral & Maxillofacial Surgery·M E Morton, W Simpson
Feb 1, 1988·The Journal of Prosthetic Dentistry·E V KluthJ C Frich
Feb 1, 1987·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J B EpsteinP Stevenson-Moore
Oct 1, 1987·Oral Surgery, Oral Medicine, and Oral Pathology·R E Marx, R P Johnson
Oct 1, 1972·American Journal of Surgery·T E DalyW S MacComb
May 1, 1983·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·R E Marx
Jun 1, 1983·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·R E Marx
Mar 1, 1984·Head & Neck Surgery·J BeumerM Kurrasch
Jul 1, 1983·Head & Neck Surgery·J BeumerM Kurrasch
Feb 1, 1980·Oral Surgery, Oral Medicine, and Oral Pathology·C G MurrayS O Zimmerman
May 1, 1980·International Journal of Radiation Oncology, Biology, Physics·C G MurrayS Zimmerman
Apr 15, 1981·Cancer·R B MorrishD Greenspan
May 1, 1980·International Journal of Radiation Oncology, Biology, Physics·C G MurrayS Zimmerman
Jul 1, 1995·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J P van MerkesteynA M Borgmeijer-Hoelen
Jan 1, 1994·International Journal of Radiation Biology·P A Riley
Jul 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S DelanianM Housset
Jan 1, 1993·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·H MinnR P Happonen
Jan 1, 1993·Clinical Oncology : a Journal of the Royal College of Radiologists·K H PigottM I Saunders
Sep 1, 1996·European Journal of Cancer. Part B, Oral Oncology·C Scully, J B Epstein
Mar 1, 1997·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·L Clayman
Jun 1, 1997·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M M Curi, L L Dib
Jul 1, 1997·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J K WongM McLean
Oct 23, 1997·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·P Reher
Sep 30, 2000·Clinical Otolaryngology and Allied Sciences·G Støre, M Boysen
Oct 6, 2000·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J J ThornL Bastholt
Apr 28, 2001·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J A Chavez, C D Adkinson

❮ Previous
Next ❯

Citations

Dec 23, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·R SchweyenT Kuhnt
Jan 6, 2012·Clinical Oral Investigations·Geert M G HommezRoeland J G De Moor
Apr 20, 2010·Oral and Maxillofacial Surgery·Felix P KochWilfried Wagner
Oct 12, 2012·Oral and Maxillofacial Surgery·Pravin N LambadeManu Goel
Jun 11, 2011·Pathology Research International·J Matthew Debnam
Jun 8, 2014·International Journal of Oral and Maxillofacial Surgery·T GanderM Bredell
Sep 15, 2012·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Naoko SaitoOsamu Sakai
Sep 24, 2011·Journal of Biomedicine & Biotechnology·Bérengère PhulpinNguyen Tran
Apr 7, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·King Chong ChanMichael J Pharoah
Sep 23, 2014·Head & Neck·Bruno Ramos ChrcanovicAnn Wennerberg
Jul 30, 2011·Oral and Maxillofacial Surgery Clinics of North America·Karla O'Dell, Uttam Sinha
Jul 19, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Peter VestergaardElse Marie Pinholt
May 12, 2010·Oral Oncology·C MadridK Bouferrache
Oct 5, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Pauline BléryNoëlle Mathieu
Mar 18, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Judith A E M ZechaRené-Jean Bensadoun
Jul 15, 2015·International Journal of Oral and Maxillofacial Surgery·Y HeZ Zhang
Jul 30, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Im Geon JinSoon Jung Hwang
Dec 29, 2015·Maxillofacial Plastic and Reconstructive Surgery·Chul-Man KimJin-Wook Kim
Aug 13, 2015·BioMed Research International·Jun Yuan LiEdmond Ho Nang Pow
May 15, 2015·The Journal of Craniofacial Surgery·Giorgia GallesioMarco Mozzati
Dec 3, 2014·Clinical Radiology·S S DeshpandeS Juvekar
Jul 19, 2016·International Journal of Oral and Maxillofacial Surgery·K GrisarC Politis
Apr 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chun-Nan YehMiin-Fu Chen
May 5, 2018·Current Opinion in Otolaryngology & Head and Neck Surgery·Blake S Raggio, Ryan Winters
Jul 6, 2018·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Christian M MeerweinMartin W Huellner
Jan 23, 2016·HNO·G SchnurbeinR O Seidl
May 2, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Karen E EffingerSharon M Castellino
Aug 8, 2019·Current Opinion in Otolaryngology & Head and Neck Surgery·Kareem Haroun, Orly M Coblens
Mar 14, 2020·Oral Diseases·Fred K L SpijkervetArjan Vissink
May 8, 2020·International Journal of Oncology·Jie LiSilian Fang
Aug 12, 2019·Clinical Oral Investigations·Mayra Cristina YamasakiLourenço Correr-Sobrinho
Dec 5, 2013·Clinical Nuclear Medicine·Constantin LapaKen Herrmann
Nov 28, 2019·Animal Models and Experimental Medicine·Ana Luisa Riul SórioKarina Fittipaldi Bombonato-Prado
Jul 19, 2011·Journal of Cellular and Molecular Medicine·Sarvpreet SinghGünter Lepperdinger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Batya R GoldwaserMeredith August
International Journal of Radiation Oncology, Biology, Physics
Franz-Josef ProttJosef Piffko
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Takashi KikuiriSongtao Shi
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
N YaromS Elad
© 2021 Meta ULC. All rights reserved