PMID: 2494840Jan 1, 1989Paper

Osteosarcoma and interferon. Studies of human xenografts in the nude mouse

Acta Orthopaedica Scandinavica. Supplementum
O Brosjö

Abstract

This work assessed the transplantability of human osteosarcomas to immunodeficient nude mice. Osteosarcomas serially transplanted in nude mice were characterized by growth rate, histologic features, and nuclear DNA content. The osteosarcoma xenografts were used to investigate the antitumor effects of interferon (IFN). Tumor tissue from 25 primary osteosarcomas was transplanted into nude mice. All tumors were histologically of high grade (III-IV). Flow DNA cytometry disclosed that all, except 1, had a nondiploid DNA content. 14 of the 25 osteosarcomas grew in serial passage in nude mice, i.e., the take rate was 0.6. The transplantable osteosarcoma group was characterized by a predominance of Grade IV lesions, and a high proportion of proliferating cells, compared to the nontransplantable. The 14 osteosarcoma xenografts, established in nude mice, were heterogeneous with respect to growth rate, histologic subtype, DNA content, and proliferative activity. However, the osteosarcomas retained the basic characteristics of their respective original tumor; the xenografts exhibited the same histologic appearance and DNA content in the first 2 passages in nude mice. During serial transplantation of the 14 osteosarcomas, the histologic fea...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.