Osteosarcoma and pulmonary metastases: 15-year experience from a single institution

The Australian and New Zealand Journal of Surgery
P M EllisP Stalley

Abstract

The outcome of management in patients with osteosarcoma and pulmonary metastases at a Sydney teaching hospital was reviewed. A retrospective review was undertaken of all patients diagnosed with osteosarcoma and treated by the Bone and Soft Tissue Unit and the Medical Oncology Department, Royal Prince Alfred Hospital between 1979 and January 1995. Information was collected on demographics, tumour site, tumour histology, primary management including surgery and adjuvant therapy, and the subsequent development and management of pulmonary metastases. A total of 56 patients with localized osteosarcoma was seen. Overall survival and survival following pulmonary metastases was assessed. There were 33 (59%) males and 23 (41%) females, with a median age of 27 years. Survival at 5 years, for patients with non-axial osteosarcoma was 60% (95% CI, 44-77%). Pulmonary metastases without other metastatic disease being apparent, developed in 22 patients, of whom 12 underwent surgical resection. The median disease-free interval of these latter patients was 20 months (95% CI, 8-32 months). Median survival among patients not undergoing surgical resection was 5 months from detection of metastases. Patients undergoing resection of pulmonary metastas...Continue Reading

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Citations

Mar 16, 2004·Journal of Pediatric Surgery·Wendy T SuMichael P La Quaglia
Jan 16, 2002·The Annals of Thoracic Surgery·G Le GarffP Delaval
Mar 2, 2016·Pediatric Blood & Cancer·Tracy A MarkoLogan G Spector
Nov 8, 2001·Journal of Drug Education·C R CollierU Pitre
Dec 7, 2013·Expert Review of Anticancer Therapy·Nataraj Vijayamurugan, Sameer Bakhshi
Apr 16, 2002·Clinical Orthopaedics and Related Research·Roby C ThompsonChap T Le
May 8, 2001·Cancer Investigation·W S Ferguson, A M Goorin
Aug 8, 2002·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·P BüchlerT Lehnert

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