PMID: 15218420Jun 26, 2004Paper

Osteosarcoma as a second tumor after treatment for primary non-Hodgkin's lymphoma in a child with ataxia-telangiectasia: presentation of a case and review of possible pathogenetic mechanisms

Journal of Pediatric Hematology/oncology
Alexandros MakisStavros Haidas

Abstract

Patients with ataxia-telangiectasia (A-T) and cancer are exposed to additional toxicity due to their underlying inability to repair chemotherapy-induced DNA damage. The authors report the development of osteosarcoma as a second neoplasia in a child with A-T who was treated, without being irradiated, for non-Hodgkin's lymphoma as a primary malignancy. This is the first report of osteosarcoma associated with A-T. The authors postulate that the mechanisms of carcinogenesis are common and independent of the different histopathology categories of these two neoplasias, and the underlying "canvas" of the A-T mutated gene was further triggered by chemotherapy, leading to the development of a second malignancy.

References

May 1, 1975·The British Journal of Radiology·P N CunliftH N Ward
May 1, 1990·Cancer Genetics and Cytogenetics·F Hecht, B K Hecht
Nov 1, 1990·Cancer Genetics and Cytogenetics·D MorrellM Swift
Sep 1, 1987·British Journal of Cancer·J E KingstonL M Kinnier Wilson
May 21, 1987·The New England Journal of Medicine·M SwiftC L Chase
Jul 1, 1993·Current Opinion in Oncology·N Fuchs, K Winkler
Dec 4, 1998·Medical and Pediatric Oncology·C Sandoval, M Swift
Apr 13, 1999·Pediatric Radiology·R C MurphyJ B Campbell
Dec 22, 1999·American Journal of Clinical Oncology·A UlusakaryaJ N Munck
Nov 1, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R J Michelson, T Weinert
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A T Meadows
Dec 18, 2001·Genes, Chromosomes & Cancer·Carl W MillerH Phillip Koeffler
Dec 5, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Merlin R HamreMichael P Mott

❮ Previous
Next ❯

Citations

Apr 25, 2013·Journal of Pediatric Hematology/oncology·Ana Pérez-VillenaEsther Aleo
Sep 7, 2005·Pharmacogenomics·James M Allan, Charles S Rabkin
Apr 5, 2011·Immunopharmacology and Immunotoxicology·Valerio CecinatiBaldassarre Martire

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Ataxia telangiectasia

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.