Osteosarcoma in patients younger than 12 years old without metastases have similar prognosis as adolescent and young adults

Pediatric Blood & Cancer
Sabrina Jeane Prates EleutérioAntonio Sergio Petrilli

Abstract

Childhood cancer is relatively rare and tends to present specific age distribution, as a prognostic factor for some of these diseases. Information on how young age affects prognosis, response to chemotherapy, and local control options in children versus AYA with osteosarcoma (OST) is minimal. In order to identify the main differences in clinical pathologic features, surgical approaches and survival rates of primary high grade OST of the extremity between children (n = 156; <12 years old) and AYA (n = 397; 12-30 years old), the institutional database with 553 patients treated by BOTG studies over 15 years were reviewed. There were no differences in metastases at diagnosis, tumor size, and grade of necrosis between the two age groups. The rate of amputation was 30% higher in the children group (P = 0.018). The rate of limb salvage surgery using reconstruction with allograft or autograft was 70% higher in the children group (P = 0.018) while endoprosthesis rate was 40% higher in the AYA group (P = 0.018). The log rank test revealed that survival is similar between the two age groups for non-metastatic patients (P = 0.424 for OS and P = 0.393 for EFS). Metastatic patients of both ages group had higher risk of dying compared to non-...Continue Reading

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Citations

Oct 1, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhen YangXiaoke Sun
Mar 8, 2017·Journal of Pediatric Hematology/oncology·Jeong A Park, Hee Young Shin
Mar 13, 2018·Clinical Orthopaedics and Related Research·Luis A Aponte-TinaoGerman L Farfalli
May 16, 2019·Clinics·Nathalie Vieira BalmantBeatriz de Camargo
May 21, 2019·Journal of Pediatric Hematology/oncology·Ahmed M MorsyMaha S El-Naggar
Aug 21, 2020·Journal of Cellular and Molecular Medicine·Yiyang YuWei Guo
Aug 20, 2018·BMC Musculoskeletal Disorders·Takashi FukushimaAkira Kawai
Aug 23, 2019·Technology in Cancer Research & Treatment·Xiao MaCheng Liu
Jun 2, 2020·The Bone & Joint Journal·Yongsung KimHan-Soo Kim
Mar 20, 2020·Molecular and Clinical Oncology·Kazuhiko HashimotoMasao Akagi

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