Abstract
About 11,600 cases of laryngeal cancer were reported in the United States in 1995, accounting for 1% of all reported cancers. Fewer than 1% of laryngeal cancers are sarcomas, osteosarcoma being the rarest type. Twelve cases of laryngeal osteosarcoma have been cited in the literature. A 47-year-old man presented with hoarseness following a benign vocal polypectomy. The entire larynx appeared swollen, although both vocal folds moved well. Biopsies did not reveal pathologic tissue. Computed tomographic imaging revealed a destructive, expansile lesion of the thyroid cartilage. A computed tomography-guided biopsy of this cartilage revealed a high-grade sarcoma. Laryngeal osteosarcoma was diagnosed following total laryngectomy. Laryngeal osteosarcoma is a highly malignant neoplasm with early hematogenous spread. Survival statistics for peripheral osteosarcoma are poor. Limited experience reveals that a combination of surgery and radiotherapy with adjuvant chemotherapy can offer some palliation. The literature and published cases of laryngeal osteosarcoma are reviewed.
References
Aug 1, 1978·Archives of Otolaryngology·J G HaarP S Milley
Nov 1, 1978·Cancer·L J DahmF Vellios
Jul 1, 1992·Ultrastructural Pathology·I DardickT J Colgan
Jan 1, 1992·Head & Neck·H J WaneboR H Spiro
Jun 1, 1991·Human Pathology·T HasegawaS Ishii
Mar 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J PinsolleF Siberchicot
Jul 1, 1990·The Annals of Otology, Rhinology, and Laryngology·P NicolaiJ A Kirchner
Dec 1, 1989·The Annals of Otology, Rhinology, and Laryngology·C G van LaerP M Stell
Oct 1, 1989·American Journal of Surgery·A M FreedmanJ E Woods
Oct 1, 1973·The Journal of Laryngology and Otology·A R MorleyA J Watson
Feb 1, 1966·The Laryngoscope·P M SprinkleP F Brookshire
Jan 1, 1980·Archives of Otolaryngology·A GorensteinK D Devine
Jan 1, 1994·Drugs·P PicciF Gherlinzoni
Jan 1, 1995·CA: a Cancer Journal for Clinicians·P A WingoS Bolden
May 15, 1993·Cancer·K KramerH J Cohen
Jan 1, 1997·Head & Neck·T S SheenM M Hsu
Nov 1, 1946·Archives of Otolaryngology·L H CLERF
Citations
Nov 8, 2005·International Journal of Surgical Pathology·Quirine C P LedeboerMichael A den Bakker
Jun 21, 2014·Head and Neck Pathology·Esraa MosalleumJos Hille
Jul 24, 2020·Oncology and Therapy·Antti A MäkitieAlfio Ferlito
May 16, 2014·Head & Neck·Kiyomi KubaMasashi Sugasawa
Nov 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ilhan TopalogluServet Sişman