Osteosarcoma of the spine: experience in 26 patients treated at the Massachusetts General Hospital

The Spine Journal : Official Journal of the North American Spine Society
Andrew J SchoenfeldJoseph Schwab

Abstract

Because of the low incidence, treatment recommendations for spinal osteosarcoma are guided by the results of small series and case reports. Many include patients who presented for treatment over the course of three to four decades. The goal of this investigation was to report the treatments, results, and overall survivorship of 26 patients treated for osteosarcoma of the spine at a single institution. Retrospective prognostic series (Level III evidence). Twenty-six patients treated at a single center for osteosarcoma of the spine over a 26-year period. Estimation of patient survival, local recurrence, and the presence of metastatic disease. We performed a retrospective review of cases of osteosarcoma involving the spine treated at our institution between 1982 and 2008. Medical charts, radiology reports, pathology reports, and operative notes were reviewed for all patients. Available imaging studies were also reviewed. The log-rank test was used to compare baseline differences between groups. Survivorship analysis was performed using Kaplan-Meier methodology. The effect of Paget osteosarcoma, type of resection, presence of local recurrence, tumor size, surgical margins, and metastases on overall survival were also investigated u...Continue Reading

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