PMID: 11920477Mar 29, 2002Paper

Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group

Cancer
Toshifumi OzakiStefan S Bielack

Abstract

Due to the low incidence rate, the optimal strategy for the treatment of patients with spinal osteosarcoma is unknown. Twenty-two patients with osteosarcoma of the spine (15 with tumors of the sacrum and 7 with tumors at other sites) who received chemotherapy according to the Cooperative Osteosarcoma Study Group protocol were analyzed. Six patients presented with metastasis, and 16 patients had no evidence of metastasis at the time of entry into the protocol. Of 12 patients who underwent excision of their tumors, 2 patients underwent wide excision, 3 patients underwent marginal excision, and 7 patients underwent intralesional excision. Eight patients received irradiation: Six patients received conventional radiotherapy only, one patient received neutron beam therapy, and one patient received samarium-153-ethylene diamine tetramethylene phosphonate therapy. Follow-up ranged between 24 months and 105 months (median, 47 months). The median survival was 23 months, and three patients have survived without disease for > 6 years. Patients with primary metastases (P = 0.004), large tumors (P = 0.010), and sacral tumors (P = 0.048) had lower overall survival compared with patients who had no metastasis, small tumors, and nonsacral tumor...Continue Reading

Citations

Oct 30, 2007·Journal of Cancer Research and Clinical Oncology·Jonathan C M ClarkPeter F M Choong
Dec 19, 2013·Cancer Treatment Reviews·Anja LuetkeHeribert Juergens
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