Osteosarcopenia: the Path Beyond Controversy.

Current Osteoporosis Reports
Jesse Zanker, Gustavo Duque

Abstract

Osteosarcopenia is commonly accepted as the presence of low muscle mass and function (sarcopenia) and low bone mineral density (osteopenia and osteoporosis). Osteosarcopenia remains a topic of controversy as researchers worldwide seek to elucidate whether osteosarcopenia is associated with greater risk of negative outcomes than its component parts. This review examines the latest research and controversies, and charts a path forward. Osteosarcopenia may occur in 5-37% of community-dwelling adults over the age of 65. This wide range is driven by variation in population, setting, and definitions applied. These differences in study design have resulted in mixed findings in associations with adverse outcomes for older adults living with osteosarcopenia. Research into interventions to prevent or treat osteosarcopenia, such as exercise, protein supplementation, and pharmacotherapy, is in its infancy but examined herein. The absence of a consensus operational definition of sarcopenia, and inaccurate measures of muscle mass, has hampered global progress in the field. We present a case for the path forward by reflecting on our recent history.

References

Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Adrian S DobsCarla P Roberts
Aug 23, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·William J EvansStefan D Anker
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Jun 7, 2011·Journal of the American Medical Directors Association·John E MorleyUNKNOWN Society on Sarcopenia, Cachexia and Wasting Disorders Trialist Workshop
Dec 12, 2012·Epidemiologic Reviews·Laura A SchaapMarjolein Visser
Jan 28, 2014·Journal of the American Medical Directors Association·Liang-Kung ChenHidenori Arai
Apr 17, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Stephanie A StudenskiMaria T Vassileva
Apr 18, 2014·Journal of Cachexia, Sarcopenia and Muscle·Michael J OrmsbeeLynn Panton
Apr 26, 2014·Journal of Applied Physiology·Richard V ClarkWilliam J Evans
Dec 17, 2014·Journal of the American Medical Directors Association·Ya Ruth HuoGustavo Duque
Oct 22, 2015·Climacteric : the Journal of the International Menopause Society·J A KanisE V McCloskey
Oct 31, 2015·The Lancet. Diabetes & Endocrinology·Clemens BeckerUNKNOWN STEADY Group
Aug 12, 2016·Journal of Korean Medical Science·Jun Il YooMoon Jib Yoo
Jul 25, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H P HirschfeldG Duque
Jun 14, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Peggy M CawthonUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Oct 13, 2018·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2
Dec 1, 2018·The Journal of Nutrition, Health & Aging·E DentB Vellas
Dec 21, 2018·Journal of the American Geriatrics Society·Jesse Zanker, Gustavo Duque
Jan 24, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Koeun LeeKyung Won Kim
Mar 2, 2019·Current Osteoporosis Reports·Katerina TrajanoskaDavid Karasik
Mar 23, 2019·Journal of Cachexia, Sarcopenia and Muscle·William J EvansPeggy M Cawthon

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Citations

Mar 24, 2020·Journal of Cachexia, Sarcopenia and Muscle·Ben KirkGustavo Duque
Jul 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Maryam KazemiMarla E Lujan
Jan 25, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Béatrice BouvardErick Legrand
Mar 20, 2021·Calcified Tissue International·Tim Rolvien, Michael Amling
Apr 16, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Maryam KazemiPhilip D Chilibeck
Apr 21, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z TengS Lu
Jun 29, 2021·The Journal of Nutrition, Health & Aging·G Duque
Jul 27, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jiangtao MaHongxing Huang
Nov 12, 2021·Archives of Endocrinology and Metabolism·Luciana Muniz PechmannVictoria Z C Borba

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