Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury

Journal of Neuroinflammation
Yang XiaJingxian Yang

Abstract

Neuroendoscopy is an innovative technique for neurosurgery that can nonetheless result in traumatic brain injury. The accompanying neuroinflammation may lead to secondary tissue damage, which is the major cause of delayed neuronal death after surgery. The present study investigated the capacity of osthole to prevent secondary brain injury and the underlying mechanism of action in a mouse model of stab wound injury. A mouse model of cortical stab wound injury was established by inserting a needle into the cerebral cortex for 20 min to mimic neuroendoscopy. Mice received an intraperitoneal injection of osthole 30 min after surgery and continued for 14 days. Neurological severity was evaluated 12 h and up to 21 days after the trauma. Brains were collected 3-21 days post-injury for histological analysis, immunocytochemistry, quantitative real-time PCR, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and enzyme-linked immunosorbent assays. Neurological function improved in mice treated with osthole and was accompanied by reduced brain water content and accelerated wound closure relative to untreated mice. Osthole treatment reduced the number of macrophages/microglia and peripheral infiltrating of neutrophils...Continue Reading

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Citations

Jul 4, 2017·International Journal of Molecular Sciences·Lalita SubediSun Yeou Kim
Jul 11, 2018·Cellular Reprogramming·Yingjia YaoJingxian Yang
Jan 23, 2019·The International Journal of Neuroscience·Yu WangRuiqin Yao
May 7, 2019·Immunopharmacology and Immunotoxicology·Liang KongJingxian Yang
May 28, 2019·Current Medicinal Chemistry·Ze WangJing-Shan Shi
May 25, 2021·Frontiers in Pharmacology·Frank Adu-NtiXin-Ming Ma

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Methods Mentioned

BETA
Fluorescence
biopsies
PCR
electrophoresis
enzyme-linked
ELISA

Software Mentioned

SPSS
BrainPath
ImageJ

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