Otitis Media: A Review, with a Focus on Alternative Treatments

Probiotics and Antimicrobial Proteins
L M T DicksC A van Reenen

Abstract

Otitis media (OM) is the accumulation of fluids in the middle ear, with or without symptoms of inflammation. The infection is caused by dysfunction or obstruction of the eustachian tube and is most commonly diagnosed in children under the age of two. The microbiology of OM differs, with Streptococcus pneumoniae, non-typeable Haemophilus influenzae and Moraxella catarrhalis the most commonly isolated pathogens. The emergence of penicillin-resistant Strep. pneumoniae, β-lactamase-producing strains, Haem. influenzae and Mor. catarrhalis is a major concern and health care costs associated with treatment are substantial, especially in cases of unresponsive treatment as a result of incorrect diagnosis. Alternative treatments such as vaccines and a nasal spray containing α-haemolytic streptococci with antimicrobial activity against OM pathogens, have been developed. The rationale behind such treatments is to induce an appropriate immune response against the pathogens and decrease bacterial colonisation in the nasopharynx. Another approach may be treatment with bacteriocins (natural antimicrobial peptides) or bacteriocin-like inhibitory substances (BLIS) produced by lactic acid bacteria. We have recently described an antibacterial pept...Continue Reading

References

Jul 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P C Appelbaum
Jul 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H J KoornhofK Klugman
Aug 1, 1991·The Journal of Infectious Diseases·R MuñozB G Spratt
Jul 1, 1995·Trends in Biotechnology·R W Jack, H G Sahl
Mar 15, 1995·FEMS Microbiology Letters·G BierbaumH G Sahl
Sep 1, 1993·FEMS Microbiology Reviews·T R Klaenhammer
Jan 1, 1993·Acta Oto-laryngologica·J M BernsteinJ Wactawski-Wende
Jan 1, 1996·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·I FujimoriT Yamada
Dec 1, 1995·International Journal of Food Microbiology·T AbeeC Hill
Feb 1, 1996·Antonie van Leeuwenhoek·J Delves-BroughtonJ Hugenholtz
Apr 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·P C Appelbaum
May 7, 1998·Molecular Microbiology·F HombléJ M Ruysschaert
May 23, 1998·The Journal of Antimicrobial Chemotherapy·I Brook, A E Gober
Sep 3, 1998·Applied and Environmental Microbiology·V G EijsinkI F Nes
Jan 23, 1999·Applied Microbiology and Biotechnology·T J Montville, Y Chen
Jan 28, 1999·The New England Journal of Medicine·T HeikkinenT Chonmaitree
Apr 17, 1999·Science·C Potera
Aug 25, 1999·The Journal of Antimicrobial Chemotherapy·B AmorenaJ Hernández-Yago
Sep 24, 1999·The Pediatric Infectious Disease Journal·I Brook, P Yocum
Sep 24, 1999·International Journal of Antimicrobial Agents·M B WachsmanC E Coto
Oct 8, 1999·The Journal of Antimicrobial Chemotherapy·W Witte
Nov 30, 1999·International Journal of Pediatric Otorhinolaryngology·J O Klein
Nov 30, 1999·International Journal of Pediatric Otorhinolaryngology·J M Bernstein
Dec 11, 1999·Biochimica Et Biophysica Acta·E Breukink, B de Kruijff
Jan 21, 2000·FEMS Microbiology Reviews·S EnnaharA Ishizaki
Aug 2, 2000·Archives of Otolaryngology--head & Neck Surgery·I Brook, A E Gober
Aug 5, 2000·International Journal of Antimicrobial Agents·E Leibovitz, R Dagan
Jan 3, 2001·The New England Journal of Medicine·C G WhitneyUNKNOWN Active Bacterial Core Surveillance Program of the Emerging Infections Program Network

❮ Previous
Next ❯

Citations

Jul 19, 2013·Future Medicinal Chemistry·Margaret A RileyRobert L Dorit
May 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alisha PrasadManas Ranjan Gartia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.