PMID: 6989724Mar 27, 1980Paper

Oto-rhino-laryngological diseases in patients with advanced kidney failure after kidney transplantation

Fortschritte der Medizin
H Mitschke

Abstract

Within a period of 7 years a total of 113 patients could be oto-rhino-laryngologically examined. The cases comprise chronic uremic patients under conservative therapy, patients with chronic intermittent haemodialysis treatment, and patients after successful renal transplantation. In 52% of all patients examined an impairment of hearing can be diagnosed and specified as inner ear deafness. As common etiological factors for inner ear deafness can be excluded, an accumulation of so-called uremic toxins is regarded to be the most probable cause of uremic deafness. This is confirmed by the fact that uremic deafness is not affected by haemodialysis treatment, but can be influenced favorably by a normal transplant function. Besides infiltrations of chronic inflammation and metaplasia of epithelium, nasal biopsies on uremic patients yielded histological findings invariably showing wide, thin-walled vessels in the subepithelium and the stroma. This phenomenon is possibly another pathogenic factor for epistaxis in chronic uremic patients. The depression of immunological resistance in uremia and the medication of immunosuppressive drugs after renal transplantation may explain the fact that serious otorhino-laryngological injections could ...Continue Reading

Related Concepts

Epistaxis
Hemodialysis
Kidney Failure, Chronic
Otitis Media
Pharyngeal Diseases
Rhinitis, Vasomotor
Uremia
Kidney Transplantation
Hearing Impairment

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