PMID: 7541931Jan 1, 1995Paper

Ototoxic antibiotics: a review

Acta Oto-laryngologica. Supplementum
J Wersäll

Abstract

Fifty years of experience with aminoglycoside antibiotics has confirmed their usefulness in many infections with Gram-negative bacteria. The ototoxic action has been investigated clinically in patients and in numerous animal studies. The increased knowledge about molecular structure, pharmacology and pharmacokinetics as well as information of the site of action in the labyrinth has resulted in reduced risks for severe toxic damage in kidneys and in the ear. Nevertheless, a number of cases of severe hearing loss and a few cases of deafness still occur every year. Further studies on modified molecular structure as well as site of action at the molecular level and ways of avoiding toxicity will make this group of antibiotics still more useful.

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Citations

Aug 29, 2003·Journal of the Association for Research in Otolaryngology : JARO·Shun-Ichi Imamura, Joe C Adams
Aug 29, 2003·Journal of the Association for Research in Otolaryngology : JARO·Shun-Ichi Imamura, Joe C Adams
Jan 14, 2000·European Journal of Pharmacology·S C HarveyH A Kirst
Dec 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·B MalgrangeG Moonen
May 11, 2005·Auris, Nasus, Larynx·Takeshi OkudaHiroshi Yamashita
Jul 28, 2005·The Journal of Antimicrobial Chemotherapy·Josée E Roy-LeonD William Cameron
Aug 7, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Pavlos PavlidisDimitrios Kouvelas
Jan 16, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Markus L Y M OeiFrans W J Albers
Apr 5, 2002·Biopharmaceutics & Drug Disposition·Eiichi AkahoRyuichi Kanamori

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