Ototoxic protection of sodium thiosulfate: daily vs constant infusion

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Rose Mary S StocksJerome W Thompson

Abstract

Compare the effect of a daily dose of sodium thiosulfate (STS) to continuous infusion of STS on Hartley albino guinea pig (HAGP) on cisplatin (CP)-induced sensorineural hearing loss. Study design Prospective randomized pilot study comparing a single daily dose of STS to a constant controlled infusion of STS given the middle ear space (MES) with an ototoxic regimen of CP. The hearing thresholds will be obtained by auditory brainstem response (ABR) 1 week before and after treatment. Treatment effects on responses at 2, 8, and 16 kHz signals will be investigated by an analysis of variance with one between subjects' condition and two within subjects' conditions. Basic science laboratory. STS protection resulted in significantly less hearing loss post-treatment for the protected ears. Guinea pigs with continuous infusion of STS demonstrated less loss in the protected ear than those who received the single daily dose. As expected, hearing loss at 2 kHz was less than that at 8 and 16 kHz. A continuous infusion of STS directly to the MES is better than a single daily dose of STS to the MES in reducing the ototoxicity of CP. Any targeted protection, whether by continuous infusion or daily dose, is better than no protection against the s...Continue Reading

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Citations

May 23, 2009·Annals of Tropical Paediatrics·H YapicioğluM H Ozbek
Oct 14, 2008·Advanced Drug Delivery Reviews·Erin E Leary SwanJeffrey T Borenstein
Apr 7, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Matthew Gordon CrowsonDebara L Tucci
Jul 11, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Lars EklundIngmar Persson
Aug 30, 2018·Physiological Reviews·Jing Wang, Jean-Luc Puel
Jan 18, 2019·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Viannique RollandMathieu Côté
Dec 5, 2019·The Journal of the Acoustical Society of America·Gaëlle NaertColleen G Le Prell

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