PMID: 2495509Feb 1, 1989Paper

Ototoxicity of antimycotics

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
R R Marsh, L W Tom

Abstract

Neither otomycoses nor defects of the tympanic membrane are rare. In cases of fungal infection when the tympanic membrane is not intact, the possibility exists that antimycotic medication could enter the middle ear and diffuse into the cochlea via the round window. Five antimycotic preparations were tested for acute ototoxic potential in guinea pigs. Those containing acetic acid or propylene glycol caused appreciable elevation of brainstem response thresholds, while little or no impairment resulted from tolnaftate or clotrimazole solutions in polyethylene glycol 400.

References

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Jun 1, 1986·The Laryngoscope·S L Liston, L G Siegel
Mar 1, 1982·The Journal of Laryngology and Otology·A MaherD S Hendawy
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Citations

Dec 31, 1998·Acta Oto-laryngologica·A O IkizK Ceryan
Apr 14, 2000·The Laryngoscope·L W Tom
Mar 30, 2010·Clinics in Dermatology·Irina Vennewald, Eckart Klemm
Feb 19, 2008·International Journal of Pediatric Otorhinolaryngology·Raymundo Munguia, Sam J Daniel
Jun 5, 2007·Otolaryngologic Clinics of North America·David S HaynesPeter S Roland
May 31, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kazuya ArakawaYukio Katori
Oct 1, 1993·Otolaryngologic Clinics of North America·C M Henley, L P Rybak
Sep 1, 1994·The Veterinary Clinics of North America. Small Animal Practice·R A Rosychuk
Feb 23, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Patrick J AntonelliDustin M Lang
Aug 24, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sam J DanielOlubunmi V Akinpelu
Jan 6, 2018·Journal of Audiology & Otology·Owen Woods, Issam Saliba
Aug 14, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Serdar BaylancicekAlper Tutkun
May 31, 2019·Ear, Nose, & Throat Journal·Petros Koltsidopoulos, Charalampos Skoulakis

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