PMID: 9447930Feb 3, 1998Paper

Ototoxicity of sodium nitroprusside

Hearing Research
R S RuanK H Yeoh

Abstract

Nitric oxide (NO) not only has normal physiological roles like vasodilation and neurotransmission in the living organism, it could also have possible neurodestructive effects under certain pathological conditions. The present study aimed to determine whether direct exposure of guinea pig cochlea to a NO donor like sodium nitroprusside (SNP), or a nitric oxide synthase (NOS) inhibitor like N(G)-nitro-L-arginine methyl ester (L-NAME), would cause damage to the auditory hair cells. A piece of gelfoam was placed on the round window of the right ear of adult albino guinea pigs. It was then soaked with 0.1 ml of SNP (3.4 microM), 0.1 ml of L-NAME (9.3 microM or 18.5 microM) or 0.1 ml of injection water, the vehicle used to dissolve the above chemicals. Twelve animals receiving SNP were perfused 1 day, 2, 3 and 7 days later, with three animals being used for each survival period. Six animals receiving L-NAME were allowed to survive up to 7 days before perfusion. Eight animals receiving injection water or 0.45% saline were used as controls. With the scanning electron microscope, the inner and outer hair cells were counted over a 1 mm length of the basilar membrane in each turn of every cochlea. The results showed that, in animals treat...Continue Reading

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Citations

Apr 28, 2004·Hearing Research·K HusainL P Rybak
Nov 1, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Mahmut KarapehlivanMusa Karaman
Aug 29, 2000·Plant Science : an International Journal of Experimental Plant Biology·M C PedrosoD Durzan
Feb 5, 2004·Hearing Research·Damon A FairfieldRichard A Altschuler
Jul 23, 1999·Hearing Research·O MichelK Addicks
Jul 14, 2000·Chest·J Varon, P E Marik
Apr 21, 2001·Experimental Neurology·R S RuanK H Yeoh
Aug 17, 1999·Experimental Neurology·R S RuanK H Yeoh
Oct 11, 2005·Critical Care Medicine·Alex C VidaeffSusan M Ramin
Aug 29, 2000·The Annals of Otology, Rhinology, and Laryngology·K TabuchiJ Kusakari
Oct 13, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Cláudio Márcio Yudi IkinoNewton Macuco Capella

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