Ototoxicity resulting from combined administration of cisplatin and gentamicin

The Laryngoscope
L C RiggsG J Matz

Abstract

The hypothesis that cisplatin can augment the ototoxicity of gentamicin was tested. Seven groups of 11 guinea pigs each were given a single dose of cisplatin either alone or 14 days before, at the beginning, midway through, or at the end of a course of gentamicin administered daily for 14 days. Blood and perilymph gentamicin and cisplatin concentrations were determined in three of the animals from each group. Auditory damage was determined in the remaining 8 animals electrophysiologically by measuring the compound action potential and alternating-current cochlear potential. Hair cell damage was determined using the surface preparation technique. An augmented ototoxic effect occurred when the cisplatin was given early in the 14-day course of gentamicin and did not occur when it was given at the end of treatment.

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Citations

Oct 22, 2003·Archives of Medical Research·René Toral-MartiñónMario Shkurovich-Zaslavsky
Sep 2, 2003·Hearing Research·Stavros HatzopoulosAlessandro Martini
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Jun 8, 2000·Annals of the New York Academy of Sciences·S HatzopoulosA Martini
Aug 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Guiscardo LoritoHenryk Skarzynski
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Mar 18, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Aren BezdjianSam J Daniel
Jun 11, 1999·American Journal of Clinical Oncology·J L NagyP Lavertu
Aug 8, 2020·Expert Opinion on Drug Metabolism & Toxicology·Debashree MukherjeaLeonard Rybak

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