Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain

The International Journal of Developmental Biology
Michela Di SalvioAntonio Simeone

Abstract

Mesencephalic-diencephalic dopaminergic (mdDA) neurons control motor, sensorimotor and motivated behaviour and their degeneration or abnormal functioning is associated with important pathologies, such as Parkinsons disease and psychiatric disorders. Despite great efforts, the molecular basis and the genetic factors differentially controlling identity, survival and vulnerability to neurodegeneration of mdDA neurons of the substantia nigra (SN) and ventral tegmental area (VTA) are poorly understood. We have previously shown that the transcription factor Otx2 is required for identity, fate and proliferation of mesencephalic DA (mesDA) progenitors. By using mouse models and immunohistochemistry, we have investigated whether Otx2 is expressed also in post-mitotic mdDA neurons. Our data reveal that Otx2 is expressed in post-mitotic mesDA neurons during mid-late gestation and in the adult brain. Remarkably, Otx2 expression is sharply excluded from mdDA neurons of the SN and is restricted to a relevant fraction of VTA neurons. Otx2+-TH+ neurons are concentrated to the ventral part of the VTA. Combined expression with other regionalized VTA markers shows that Otx2+-TH+ neurons are prevalently Girk2- and Calb+ and among these, those loca...Continue Reading

Citations

Dec 12, 2013·Journal of Molecular Cell Biology·Wolfgang Wurst, Nilima Prakash
Nov 19, 2010·Molecular Neurobiology·Antonio SimeoneCarmine Tomasetti
Jul 30, 2014·Cellular and Molecular Life Sciences : CMLS·Jesse V Veenvliet, Marten P Smidt
Feb 10, 2016·Journal of Chemical Neuroanatomy·YuHong FuGlenda M Halliday
May 14, 2011·FEBS Letters·Rajiv L JoshiKenneth L Moya
Oct 28, 2015·FEBS Letters·Angela AndereggRajeshwar Awatramani
Oct 4, 2015·FEBS Letters·Gabriela O Bodea, Sandra Blaess
Aug 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Alessandro PristeràSiew-Lan Ang
Mar 31, 2012·Trends in Neurosciences·Mark A Ungless, Anthony A Grace
Jan 8, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Sandra Blaess, Siew-Lan Ang
Apr 23, 2013·Developmental Biology·Shane V HegartyGerard W O'Keeffe
Aug 29, 2012·Neurobiology of Aging·Stefanie ReyesGlenda M Halliday
May 13, 2015·Trends in Neurosciences·Stéfano Pupe, Åsa Wallén-Mackenzie
Dec 2, 2014·Cell Reports·Jean-Francois PoulinRajeshwar B Awatramani
Jan 8, 2015·Frontiers in Neuroanatomy·Lars Brichta, Paul Greengard
Jun 20, 2012·The European Journal of Neuroscience·Julia FuchsRajiv L Joshi
Apr 21, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Meige ZhengXian Lin
May 22, 2016·Journal of Neurochemistry·Daniela Maria Vogt WeisenhornWolfgang Wurst
Aug 5, 2017·Frontiers in Neuroanatomy·Marten P Smidt
Jul 8, 2017·NPJ Parkinson's Disease·Miguel A P OliveiraRonan M T Fleming
Feb 11, 2011·Developmental Neurobiology·Antonio SimeoneCarmine Tomasetti
Sep 19, 2012·Cancer Research·Ren-Yuan BaiGregory J Riggins
Jan 5, 2021·Developmental Cognitive Neuroscience·Anne T ParkAllyson P Mackey
May 28, 2015·Development·Ernest ArenasJ Carlos Villaescusa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.