PMID: 9529622Apr 8, 1998Paper

Ouabain-like factor

Current Opinion in Nephrology and Hypertension
A Goto, K Yamada

Abstract

Accumulated evidence has suggested that several sodium pump inhibitors, similar to cardiotonic steroids, are present in the human body. Ouabain-like factor, the most appealing candidate, has been found to be increased with high sodium intake and hypervolaemia, and in essential hypertension, mineralocorticoid hypertension, and pregnancy-induced hypertension. Furthermore, blocking the action of ouabain-like factor with digibind or a novel anti-ouabain agent lowers blood pressure in several models of hypertension. Several important questions remain, however, before it can be concluded that ouabain-like factor is indeed involved in the regulation of sodium homeostasis and blood pressure.

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Citations

May 25, 2002·European Journal of Biochemistry·Wilhelm Schoner
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