PMID: 25792771Jan 1, 2007Paper

Our research on proton pumping ATPases over three decades: their biochemistry, molecular biology and cell biology

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Masamitsu Futai

Abstract

ATP is synthesized by F-type proton-translocating ATPases (F-ATPases) coupled with an electrochemical proton gradient established by an electron transfer chain. This mechanism is ubiquitously found in mitochondria, chloroplasts and bacteria. Vacuolar-type ATPases (V-ATPases) are found in endomembrane organelles, including lysosomes, endosomes, synaptic vesicles, etc., of animal and plant cells. These two physiologically different proton pumps exhibit similarities in subunit assembly, catalysis and the coupling mechanism from chemistry to proton transport through subunit rotation. We mostly discuss our own studies on the two proton pumps over the last three decades, including ones on purification, kinetic analysis, rotational catalysis and the diverse roles of acidic luminal organelles. The diversity of organellar proton pumps and their stochastic fluctuation are the important concepts derived recently from our studies.

References

Jan 1, 1979·Annual Review of Biochemistry·J A DownieG B Cox
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T MikiT Yura
Nov 30, 1992·Annals of the New York Academy of Sciences·R K NakamotoM Futai
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R D NelsonS Gluck
May 15, 1991·Biochemical and Biophysical Research Communications·H HanadaM Futai
Nov 30, 1990·Biochemical and Biophysical Research Communications·Y Moriyama, M Futai
May 1, 1990·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S R Hager, R K Kalkhoff
Jul 31, 1990·Biochemical and Biophysical Research Communications·H HanadaM Futai
Jan 1, 1990·Bibliotheca nutritio et dieta·H Haenel
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M OritaT Sekiya
Nov 30, 1988·Biochemical and Biophysical Research Communications·M MaedaM Futai
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E J BowmanK Altendorf
Jan 1, 1988·The Journal of Infectious Diseases
Jul 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M FutaiL A Heppel
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H KanazawaM Futai
Apr 29, 1982·Biochemical and Biophysical Research Communications·H KanazawaM Futai
Jan 1, 1982·Annals of the New York Academy of Sciences·H Kanazawa, M Futai
May 12, 1995·The Journal of Biological Chemistry·Y MoriyamaM Futai
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·S TamuraM Futai
Feb 1, 1994·Journal of Biochemistry·Y MoriyamaM Futai
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S TamuraM Futai
Mar 1, 1996·Virchows Archiv : an International Journal of Pathology·H OkaK Yada

❮ Previous
Next ❯

Citations

Mar 25, 2010·Biochemical and Biophysical Research Communications·Mayumi Nakanishi-MatsuiMasamitsu Futai
May 24, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Anže Lošdorfer BožičRudolf Podgornik
Sep 21, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Shenggao ZhouBo Li
Jun 14, 2019·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Masamitsu FutaiMayumi Nakanishi-Matsui
Oct 17, 2019·Critical Reviews in Food Science and Nutrition·Karina Kachur, Zacharias Suntres

❮ Previous
Next ❯

Related Concepts

Related Feeds

ATP Synthases

ATP synthases are enzymes located in the inner mitochondrial membrane that catalyze the synthesis of ATP during cellular respiration. Discover the latest research on ATP synthases here.