Our sense of direction: progress, controversies and challenges

Nature Neuroscience
Kathleen E Cullen, Jeffrey S Taube

Abstract

In this Perspective, we evaluate current progress in understanding how the brain encodes our sense of direction, within the context of parallel work focused on how early vestibular pathways encode self-motion. In particular, we discuss how these systems work together and provide evidence that they involve common mechanisms. We first consider the classic view of the head direction cell and results of recent experiments in rodents and primates indicating that inputs to these neurons encode multimodal information during self-motion, such as proprioceptive and motor efference copy signals, including gaze-related information. We also consider the paradox that, while the head-direction network is generally assumed to generate a fixed representation of perceived directional heading, this computation would need to be dynamically updated when the relationship between voluntary motor command and its sensory consequences changes. Such situations include navigation in virtual reality and head-restricted conditions, since the natural relationship between visual and extravisual cues is altered.

References

Sep 1, 1979·Experimental Brain Research·J N RawlinsJ A Gray
May 22, 1992·Annals of the New York Academy of Sciences·H Reisine, T Raphan
Jan 1, 1995·Experimental Brain Research·L TelfordM Ohmi
Jan 1, 1994·Experimental Brain Research·S GlasauerA Berthoz
Jun 1, 1997·Brain Research. Cognitive Brain Research·Y P Ivanenko, R Grasso
Aug 1, 1997·The European Journal of Neuroscience·E T RollsP Georges-François
Jun 26, 1998·Trends in Neurosciences·W O Guldin, O J Grüsser
Jul 13, 1999·Hippocampus·R G RobertsonS Panzeri
Jan 14, 2000·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·J M LoomisA C Beall
Jan 13, 2001·Experimental Brain Research·G T Gdowski, R A McCrea
Apr 20, 2001·Trends in Neurosciences·P E SharpJ Cho
Aug 10, 2001·Journal of Neurophysiology·M B ZugaroS I Wiener
May 31, 2002·Experimental Brain Research·Wolfgang BeckerReinhart Jürgens
Aug 2, 2003·Journal of Neurophysiology·Robert W StackmanJeffrey S Taube
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jefferson E Roy, Kathleen E Cullen
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffrey L Calton, Jeffrey S Taube
Oct 14, 2005·Progress in Brain Research·Robert A McCrea, Anja K E Horn
Jun 15, 2006·Journal of Neurophysiology·Noah A RussellDavid K Bilkey
Jul 22, 2006·Nature Reviews. Neuroscience·Bruce L McNaughtonMay-Britt Moser
Mar 8, 2007·Annual Review of Neuroscience·Jeffrey S Taube
Jul 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joshua P BassettJeffrey S Taube
Jan 30, 2009·Journal of Neurophysiology·Vladimir Marlinski, Robert A McCrea
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ryan M Yoder, Jeffrey S Taube
Mar 14, 2009·Experimental Brain Research·Soroush G SadeghiKathleen E Cullen
Jun 18, 2010·Journal of Vestibular Research : Equilibrium & Orientation·Michael E Shinder, Jeffrey S Taube
Aug 21, 2010·The Journal of Physiology·Laurens W J BosmanChris I De Zeeuw
Sep 22, 2010·The Journal of Physiology·Jeffrey S Taube
May 19, 2011·Experimental Brain Research·Ilja FrissenMarc O Ernst
May 27, 2011·Journal of Neurophysiology·Michael E Shinder, Jeffrey S Taube
Jun 22, 2011·Current Opinion in Neurobiology·Kathleen E Cullen
Oct 11, 2011·Trends in Neurosciences·Ryan M YoderJeffrey S Taube

❮ Previous
Next ❯

Citations

Jun 14, 2018·Journal of Neurophysiology·Evangelos AnagnostouDimitri Anastasopoulos
Jul 12, 2018·Journal of Neurophysiology·Sebastian M Frank, Mark W Greenlee
Dec 19, 2018·Hippocampus·Misun Kim, Eleanor A Maguire
Nov 22, 2018·Current Opinion in Neurology·Thomas Brandt, Marianne Dieterich
Jan 30, 2019·Aging & Mental Health·Yuri AgrawalPaul B Rosenberg
Feb 12, 2019·Nature·Ravikrishnan P JayakumarJames J Knierim
Sep 25, 2019·Journal of Clinical Medicine·Jessica Isbely MontanaGiuseppe Riva
Jul 4, 2020·Cognitive Neuropsychology·Kathleen E Cullen, Lin Wang
Dec 25, 2019·Annual Review of Neuroscience·Brad K Hulse, Vivek Jayaraman
Mar 7, 2020·The Journal of Comparative Neurology·Olivia PiguetPierre Lavenex
Jun 15, 2019·The Journal of Comparative Neurology·Debora BuenoMartin Metzger
Aug 28, 2020·Frontiers in Computational Neuroscience·Edgar Bermudez-ContrerasAaron Wilber
Nov 10, 2018·Science·Jacob L S BellmundChristian F Doeller
Mar 28, 2019·Nature Reviews. Neuroscience·Kathleen E Cullen
Feb 18, 2020·Journal of Vestibular Research : Equilibrium & Orientation·A WedtgrubeA A Tarnutzer
Dec 14, 2018·Frontiers in Cellular Neuroscience·Zhixian Cheng, Yong Gu
Nov 19, 2019·Frontiers in Neural Circuits·Jean BlouinMartin Simoneau
Jan 31, 2020·Frontiers in Neurology·Hayo A BreinbauerPaul H Delano
Jun 26, 2020·Frontiers in Neural Circuits·Alexander Christoph StahnHanns-Christian Gunga
Apr 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alex T L LeongEd X Wu
Jun 17, 2020·ELife·Kateřina BenediktováHynek Burda
Jun 28, 2020·Nature Communications·Matthias NauChristian F Doeller
Aug 28, 2020·Frontiers in Molecular Neuroscience·Paul F SmithStephane Besnard
Jan 20, 2021·Cell Research·Xiaoyang Long, Sheng-Jia Zhang
Feb 14, 2021·Journal of Vestibular Research : Equilibrium & Orientation·E AnsonY Agrawal
Jan 31, 2021·Scientific Reports·Florian SchöberlAndreas Zwergal
Feb 11, 2021·Journal of Neurophysiology·Mark L Latash
May 7, 2021·Current Opinion in Physiology·Kathleen E Cullen, Omid A Zobeiri
May 12, 2021·Current Biology : CB·Elhanan Ben-YishayYoram Gutfreund
May 22, 2021·Memory & Cognition·Yasaman JabbariJudith M Shedden
Dec 29, 2020·Current Opinion in Neurobiology·Tom Flossmann, Nathalie L Rochefort
Jun 23, 2021·Current Biology : CB·Aylin Apostel, Jonas Rose
Jun 24, 2021·Scientific Reports·Tien-Thong Nguyen DoKlaus Gramann
Jul 3, 2021·Geriatrics·Henk KoppelaarMartin van Warmerdam
Jul 14, 2021·Neurotoxicology and Teratology·Charles V Vorhees, Michael T Williams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.