"Out, damned spot!"

The Journal of Investigative Dermatology
R A Spritz

Abstract

Mice transgenic for the Kit Val620Ala mutation, which in humans has been associated with progressive piebaldism, exhibit dominant white spotting but show no evidence of progressive depigmentation. These results are consistent with the previous hypothesis that progressive piebaldism might result from digenic inheritance, of the KIT(V620A) mutation that causes piebaldism and a second, unknown locus that causes progressive depigmentation.

References

Oct 28, 1976·Human Genetics·B K Davis, L D Verdol
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N V BotchkarevaB A Gilchrest
Jan 5, 2002·The Journal of Investigative Dermatology. Symposium Proceedings·T KunisadaS I Hayashi
Apr 12, 2005·Cell·Eiríkur SteingrímssonNancy A Jenkins

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Citations

Jul 31, 2007·Dermatologic Clinics·Ramon Ruiz-Maldonado
Dec 18, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·C CortelazziS Di Nuzzo

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