Out of balance: the role of evolutionary mismatches in the sex disparity in autoimmune disease.

Medical Hypotheses
Sarai M KeestraGul Deniz Salali

Abstract

Over the past century autoimmune disease incidence has increased rapidly in (post-) industrialised, affluent societies, suggesting that changes in ecology and lifestyle are driving this development. Epidemiological studies show that (i) 80% of autoimmune disease patients are female, (ii) autoimmune diseases co-occur more often in women, and (iii) the incidence of some autoimmune diseases is increasing faster in women than in men. The female preponderance in autoimmunity is most pronounced between puberty and menopause, suggesting that diverging sex hormone levels during the reproductive years are implicated in autoimmune disease development. Using an evolutionary perspective, we build on the hypotheses that female immunity is cyclical in menstruating species and that natural selection shaped the female immune system to optimise the implantation and gestation of a semi-allogeneic foetus. We propose that cyclical immunomodulation and female immune tolerance mechanisms are currently out of balance because of a mismatch between the conditions under which they evolved and (post-)industrialised, affluent lifestyles. We suggest that current changes in autoimmune disease prevalence may be caused by increases in lifetime exposure to cyc...Continue Reading

References

Jun 1, 1992·Clinical Rheumatology·J A Da Silva, T D Spector
Jun 1, 1990·Arthritis and Rheumatism·T D SpectorA J Silman
Apr 6, 1989·The New England Journal of Medicine·J KarjalainenM Knip
Jun 1, 1969·Archives of Disease in Childhood·W A Marshall, J M Tanner
Jul 1, 1983·The Journal of Clinical Endocrinology and Metabolism·D Apter, R Vihko
Jul 1, 1982·The Journal of Clinical Endocrinology and Metabolism·N AminoK Miyai
Oct 1, 1981·Metabolism: Clinical and Experimental·B ZumoffD K Fukushima
Sep 1, 1994·The Quarterly Review of Biology·S B EatonM J Konner
Aug 14, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·A Zorgdrager, J De Keyser
Nov 3, 1998·Annals of the Rheumatic Diseases·C T HoR W Wong
Nov 5, 1998·Proceedings. Biological Sciences·G Jasieńska, P T Ellison
Jan 29, 1999·Research in Immunology·S RomagnaniL Adorini
Jun 17, 2000·Trends in Endocrinology and Metabolism : TEM·E SimpsonS Davis
Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Aug 11, 2000·Maturitas·A E WlukaT D Spector
Jun 16, 2001·International Immunopharmacology·D Verthelyi
Aug 2, 2001·Nature Medicine·R G WestendorpT W Huizinga
Apr 20, 2002·Science·Maria YazdanbakhshRonald van Ree
Jul 13, 2002·Annals of the New York Academy of Sciences·José António P da Silva
Nov 8, 2002·European Neurology·Anneke Zorgdrager, Jacques De Keyser
Mar 5, 2003·Annual Review of Immunology·Ralph M SteinmanMichel C Nussenzweig
Mar 13, 2003·The Journal of Endocrinology·F TanriverdiP M G Bouloux
Jul 10, 2003·Autoimmunity Reviews·Glinda S Cooper, Berrit C Stroehla
Sep 30, 2003·Journal of Neuroscience Research·Laura TsaknaridisArthur A Vandenbark
Nov 25, 2003·Menopause : the Journal of the North American Menopause Society·Kerstin RödströmCecilia Bjoürkelund
Dec 11, 2003·American Journal of Physical Anthropology·Thomas W McDade
May 12, 2005·The Quarterly Review of Biology·Randolph M Nesse
Jun 14, 2005·Social Science & Medicine·George J ArmelagosBethany Turner
Sep 2, 2005·American Journal of Human Biology : the Official Journal of the Human Biology Council·Michael P Muehlenbein, Richard G Bribiescas
Sep 15, 2005·Archives of Neurology·Alvaro AlonsoMiguel A Hernán
Mar 15, 2006·Lancet·Denis Daneman
Aug 12, 2006·Springer Seminars in Immunopathology·Troy R Torgerson
Jan 31, 2007·Journal of Autoimmunity·Norbert Gleicher, David H Barad
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lourdes ArruvitoLeonardo Fainboim
Mar 30, 2007·Arthritis and Rheumatism·Karen H CostenbaderElizabeth W Karlson
May 17, 2007·PLoS Medicine·Alejandra Núñez-de la MoraGillian R Bentley
Oct 30, 2007·American Journal of Human Biology : the Official Journal of the Human Biology Council·Grazyna Jasienska, Michal Jasienski
Aug 9, 2008·The American Journal of Pathology·DeLisa FairweatherNoel R Rose
Aug 22, 2008·Immunological Investigations·Kristina M Adams Waldorf, J Lee Nelson
Aug 30, 2008·Blood·Jinfang Zhu, William E Paul
Oct 15, 2008·Cancer Causes & Control : CCC·Sissi Espetvedt FinstadInger Thune
Jan 28, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S V RamagopalanUNKNOWN Canadian Collaborative Study Group
Feb 26, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kathleen A O'ConnorMaxine Weinstein
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Arnaud Nicot
Apr 1, 2009·Arthritis and Rheumatism·Marie-Odile BernierSamy Suissa
May 26, 2009·Immunity·Liang ZhouDan R Littman
Nov 20, 2009·Immunology·Ariana Peck, Elizabeth D Mellins

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Aug 16, 2021·Ageing Research Reviews·Aurelia SantoroDaniela Monti

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