Out-of-field dose studies with an anthropomorphic phantom: comparison of X-rays and particle therapy treatments

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
C La TessaM Durante

Abstract

Characterization of the out-of-field dose profile following irradiation of the target with a 3D treatment plan delivered with modern techniques. An anthropomorphic RANDO phantom was irradiated with a treatment plan designed for a simulated 5 × 2 × 5 cm(3) tumor volume located in the center of the head. The experiment was repeated with all most common radiation treatment types (photons, protons and carbon ions) and delivery techniques (Intensity Modulated Radiation Therapy, passive modulation and spot scanning). The measurements were performed with active diamond detector and passive thermoluminescence (TLD) detectors to investigate the out-of-field dose both inside and outside the phantom. The highest out-of-field dose values both on the surface and inside the phantom were measured during the treatment with 25 MV photons. In the proximity of the Planned Target Volume (PTV), the lowest lateral dose profile was observed for passively modulated protons mainly because of the presence of the collimator in combination with the chosen volume shape. In the far out-of-field region (above 100mm from the PTV), passively modulated ions were characterized by a less pronounced dose fall-off in comparison with scanned beams. Overall, the trea...Continue Reading

References

Jun 10, 2008·Physics in Medicine and Biology·X George XuHarald Paganetti
Jul 8, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Michael Goitein
Dec 2, 2009·Nature Reviews. Clinical Oncology·Marco Durante, Jay S Loeffler
Feb 27, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Herman SuitAlexei Trofimov
May 20, 2011·Nature Reviews. Cancer·Wayne D Newhauser, Marco Durante
Oct 14, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Detlef BartkowiakThomas Wiegel

❮ Previous
Next ❯

Citations

Sep 24, 2013·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·J Malicki, M Peszynska-Piorun
Mar 13, 2013·Acta Oncologica·Ludvig P MurenBengt Glimelius
Mar 11, 2015·Radiation Protection Dosimetry·W RühmC Woda
Apr 15, 2015·Radiation Protection Dosimetry·A OttolenghiUNKNOWN ANDANTE Consortium
Dec 10, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ludvig P Muren, David I Thwaites
Dec 3, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael LishnerFrederic Amant
May 22, 2013·Nature Reviews. Clinical Oncology·Jay S Loeffler, Marco Durante
Jun 13, 2018·Journal of Cancer Research and Therapeutics·Mohammad Taghi Bahreyni ToossiDavid Davenport
Aug 20, 2016·Reports on Progress in Physics·Marco Durante, Harald Paganetti
Jan 1, 2016·International Journal of Particle Therapy·Francesco TommasinoMarco Durante
Jul 21, 2021·Life Sciences in Space Research·Walter TinganelliMarco Durante

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Basit S Athar, Harald Paganetti
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Francesca AlbertiniGudrun Goitein
Physics in Medicine and Biology
Antje-Christin Knopf, Antony J Lomax
© 2021 Meta ULC. All rights reserved