Out of the Randomness: Correlating Noise in Biological Systems

Biophysical Journal
Maddalena ColliniGiuseppe Chirico

Abstract

The study of the dynamics of biological systems requires one to follow relaxation processes in time with micron-size spatial resolution. This need has led to the development of different fluorescence correlation techniques with high spatial resolution and a tremendous (from nanoseconds to seconds) temporal dynamic range. Spatiotemporal information can be obtained even on complex dynamic processes whose time evolution is not forecast by simple Brownian diffusion. Our discussion of the most recent applications of image correlation spectroscopy to the study of anomalous sub- or superdiffusion suggests that this field still requires the development of multidimensional image analyses based on analytical models or numerical simulations. We focus in particular on the framework of spatiotemporal image correlation spectroscopy and examine the critical steps in getting information on anomalous diffusive processes from the correlation maps. We point out how a dual space-time correlative analysis, in both the direct and the Fourier space, can provide quantitative information on superdiffusional processes when these are analyzed through an empirical model based on intermittent active dynamics. We believe that this dual space-time analysis, ...Continue Reading

References

Nov 1, 1976·Biophysical Journal·D E KoppelW W Webb
Aug 1, 1996·Biophysical Journal·G Chirico, J Langowski
Nov 28, 1994·Physical Review Letters·R N Mantegna, H E Stanley
Mar 20, 2002·Cell Biochemistry and Biophysics·P Schwille
May 29, 2003·Biophysical Journal·Matthias WeissTommy Nilsson
May 24, 2005·Biophysical Journal·Michelle A DigmanEnrico Gratton
Oct 4, 2005·Biophysical Journal·Laure WawrezinieckPierre-François Lenne
Jul 22, 2006·The EMBO Journal·Pierre-François LenneDidier Marguet
May 20, 2008·Biophysical Journal·Jianrong Wu, Keith M Berland
Mar 18, 2009·Biophysical Journal·Ariel Lubelski, Joseph Klafter
Aug 8, 2009·Physical Review Letters·Jedrzej Szymanski, Matthias Weiss
Dec 1, 2010·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Christian C Fritsch, Jörg Langowski
Jan 12, 2011·Annual Review of Physical Chemistry·Michelle A Digman, Enrico Gratton
Mar 17, 2011·Physical Review Letters·Jae-Hyung JeonRalf Metzler
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Aubrey V WeigelDiego Krapf
Sep 3, 2011·PloS One·Thomas KühnJussi Timonen
Jan 3, 2012·Biophysical Journal·Elliot L Elson
May 23, 2012·Nature Materials·Bo WangSteve Granick
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·S M Ali TabeiNorbert F Scherer
Mar 14, 2013·Reports on Progress in Physics·Felix Höfling, Thomas Franosch
Jul 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Carmine Di RienzoFrancesco Cardarelli
Dec 18, 2013·Annual Review of Physical Chemistry·Nirmalya Bag, Thorsten Wohland
Jan 2, 2014·International Review of Cell and Molecular Biology·Matthias Weiss
Aug 16, 2014·Current Opinion in Structural Biology·Thomas WeidemannPetra Schwille
Sep 13, 2014·Physical Review Letters·Mykyta V Chubynsky, Gary W Slater
Dec 6, 2014·Scientific Reports·Laura SironiGiuseppe Chirico
Dec 24, 2014·Nature Communications·Carmine Di RienzoFrancesco Cardarelli
Aug 25, 2015·Nature Communications·I BronshteinY Garini
Nov 6, 2015·Nature Protocols·Jan W KriegerThorsten Wohland
Jan 16, 2017·Biophysical Journal·Thomas J LampoAndrew J Spakowitz
Feb 6, 2017·Chemical Reviews·Kamilla NorregaardLene B Oddershede

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