Outbreak investigation of Candida auris at a tertiary care hospital in Karachi, Pakistan.

Journal of Infection Prevention
Joveria Q FarooqiRana J Asghar

Abstract

From September 2014, a tertiary care hospital in Karachi, Pakistan, started diagnosing 3-5 cases/month of a yeast locally identified as Saccharomyces spp. resistant to fluconazole. US Centers for Disease Control and Prevention identified the isolates as Candida auris. The Pakistan Field Epidemiology and Laboratory Training Program (FELTP) and the hospital investigated the outbreak from April 2015 to January 2016. The aim of the outbreak investigation was to determine the risk factors and to inform measures to limit the spread of the organism in the hospital. Medical records, nursing schedules and infection control practices were reviewed. Sixty-two age- and sex-matched hospital controls from the same wards were identified. Thirty cases (17 males) were identified (mean age = 51.6 years, age range = 2-91 years), case fatality was 53%. Multivariate logistic regression showed that a history of surgery within 90 days of diagnosis, admission to the emergency department and history of chronic kidney disease were significantly associated with C. auris infection. This is the report of the outbreak investigation that triggered a global exploration of C. auris as a newly identified multidrug-resistant nosocomial organism, spreading within...Continue Reading

References

Sep 21, 2013·Emerging Infectious Diseases·Anuradha ChowdharyJacques F Meis
Jun 26, 2014·Emerging Infectious Diseases·Rindidzani E MagoboNelesh P Govender
May 20, 2015·Emerging Infectious Diseases·Maha EmaraRitu Bafna
Oct 26, 2016·Antimicrobial Resistance and Infection Control·Silke SchelenzMatthew C Fisher
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May 8, 2019·BMC Infectious Diseases·Muneeba Ahsan SayeedSyed Faisal Mahmood

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