Outbreak of coagulase negative staphylococcus highly resistant to ciprofloxacin in a leukaemia unit

BMJ : British Medical Journal
B A OppenheimJ P Burnie

Abstract

To define an outbreak of bacteraemia due to coagulase negative staphylococci highly resistant to ciprofloxacin in a leukaemia unit, investigate the source and mode of spread of the outbreak strain, and assess control measures. The outbreak strain was characterised by five different typing methods. Surveillance of patients, staff, and environment was carried out during the outbreak and five months after control measures were introduced. A unit with 10 beds for adults with leukaemia and patients receiving bone marrow transplants. The outbreak occurred during a trial of ciprofloxacin for empirical treatment of neutropenic fevers. Ciprofloxacin was withdrawn from use in the unit and daily bathing with chlorhexidine gluconate solution started. Main outcome measure--The absence of bacteraemia due to the outbreak strain for five months after control measures. During the study 49 patients developed 21 episodes of bacteraemia due to the outbreak strain, which was ciprofloxacin resistant (minimum inhibitory concentration greater than or equal to 128 mg/l), susceptible to phage 155 A9C, and SII biotype and had characteristic immunoblot and DNA fingerprint features. There was a high amount of colonisation of patients but not staff with thi...Continue Reading

References

Nov 19, 1977·British Medical Journal·M Casewell, I Phillips
Jul 29, 1989·BMJ : British Medical Journal·B A OppenheimJ P Burnie
Aug 17, 1985·Lancet·H Humphreys, E Mulvihill
Oct 26, 1985·Lancet·G M SmithM J Leyland
Oct 1, 1985·Antimicrobial Agents and Chemotherapy·J S Wolfson, D C Hooper
Jul 1, 1988·Clinical Microbiology Reviews·M A Pfaller, L A Herwaldt
Jan 1, 1988·Journal of Clinical Pathology·J P BurnieR Bayston
Jun 26, 1987·Journal of Immunological Methods·J Burnie, R C Matthews
Jun 1, 1986·Computer Methods and Programs in Biomedicine·C L Webber
Oct 5, 1985·British Medical Journal·P J van den BroekR P Mouton
Aug 1, 1983·Journal of Clinical Microbiology·G D ChristensenE H Beachey
Jan 1, 1983·Archives of Internal Medicine·D J WinstonW J Martin

❮ Previous
Next ❯

Citations

Feb 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·O LyytikäinenV Valtonen
Jun 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S M KelseyA C Newland
Jun 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J WiltonJ I Flock
Apr 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·U B Schaad
Nov 5, 2002·Critical Reviews in Oncology/hematology·C S M Oude NijhuisEveline S J M de Bont
Jul 14, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juan J Picazo
Mar 26, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Melissa E SandersMary E Marquart
Mar 14, 2009·The Journal of Antimicrobial Chemotherapy·F Kate GouldUNKNOWN MRSA Working Party of the British Society for Antimicrobial Chemotherapy
Oct 1, 1994·Antimicrobial Agents and Chemotherapy·G L Archer, M W Climo
Apr 1, 1994·Antimicrobial Agents and Chemotherapy·W V KernR Marre
Jul 29, 1989·BMJ : British Medical Journal·B A OppenheimJ P Burnie
Jan 31, 2008·Leukemia & Lymphoma·Sarah P Hammond, Lindsey R Baden
Oct 1, 2011·Cancer Letters·Vasileios KouranosKostas N Syrigos
Dec 1, 1996·Infectious Disease Clinics of North America·S J Chanock, P A Pizzo
Jun 1, 1997·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Gerda T. NoordhoekJohn E. Degener
Jul 10, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Werner E BischoffRobert J Sherertz
Nov 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mario CrucianiCarlo Mengoli
Dec 20, 1999·The Journal of Antimicrobial Chemotherapy·K G Kerr
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Del Favero, F Menichetti
Sep 1, 1991·The Journal of Hospital Infection·R E Warren
Jan 20, 2012·The Cochrane Database of Systematic Reviews·Anat Gafter-GviliLeonard Leibovici
Dec 3, 2003·Bone Marrow Transplantation·J A Pérez-SimónJ F San Miguel
Dec 1, 1990·British Journal of Haematology·S R SmithJ M Davies
Mar 2, 2006·The Journal of Antimicrobial Chemotherapy·Curtis G GemmellUNKNOWN Joint Working Party of the British Society for Joint Working Party of the British Society for Antimicrobial Chemotherapy, Ho
Jan 1, 1995·Scandinavian Journal of Infectious Diseases·O LyytikäinenJ Vuopio-Varkila
Jan 1, 1997·The Pediatric Infectious Disease Journal·A Freifeld, P Pizzo
Oct 1, 1990·Journal of Chemotherapy·P MapleJ M Hamilton-Miller
Oct 1, 1995·Clinical Microbiology Reviews·N WoodfordD C Speller

❮ Previous
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