Outbreak of extended-spectrum beta-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a French hospital.

Journal of Clinical Microbiology
Laurent PoirelPatrice Nordmann

Abstract

Twelve clonally related and multidrug-resistant Acinetobacter baumannii isolates were recovered during a 4-month period from 12 patients hospitalized at the Valenciennes Hospital in France. Antibiograms determined by the double-disk diffusion technique on cloxacillin-containing plates detected a clavulanic acid-inhibited extended-spectrum beta-lactamase (ESBL). PCR and sequencing identified the gene encoding the Ambler class A ESBL VEB-1. This gene was located on the chromosome and was part of a class 1 integron identical to that previously identified in Pseudomonas aeruginosa isolates from Thailand. Additionally, seven clonally related bla(VEB-1)-positive A. baumannii strains were identified in the immediate environment of the hospitalized patients. This is the first report of the ESBL VEB-1 in Acinetobacter spp. and the first description of VEB-1-producing strains as a source of an outbreak occurring outside Southeast Asia. This report underlines the difficulty of the identification of ESBLs in A. baumannii.

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Citations

Feb 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pierre Edouard Fournier, Hervé Richet
Aug 9, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert A Bonomo, Dora Szabo
May 21, 2008·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Xiao-Lin YinLin Wei
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Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Fernando PasteránViviana Cagnoni
Aug 26, 2009·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Aug 18, 2010·Antimicrobial Agents and Chemotherapy·Jose-Manuel Rodriguez-MartinezPatrice Nordmann
May 2, 2012·Antimicrobial Agents and Chemotherapy·C C PapagiannitsisL S Tzouvelekis
Jun 28, 2006·Antimicrobial Agents and Chemotherapy·Jose-Manuel Rodriguez-MartinezPatrice Nordmann
Dec 15, 2010·Antimicrobial Agents and Chemotherapy·Delphine GirlichPatrice Nordmann
Jan 16, 2008·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Jul 25, 2007·Antimicrobial Agents and Chemotherapy·Federico PerezRobert A Bonomo
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Xiaofei JiangYuan Lu
May 2, 2007·Antimicrobial Agents and Chemotherapy·Marie-Frédérique LartiguePatrice Nordmann
Nov 25, 2004·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
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