PMID: 8943928Nov 15, 1996Paper

Outbreak of measles in a highly vaccinated secondary school population

CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
P A Sutcliffe, E Rea

Abstract

To examine the factors associated with measles vaccine effectiveness and the effect of two doses of vaccine on measles susceptibility during an outbreak. Retrospective cohort study. A secondary school in the City of Toronto. The entire school population (1135 students 14 to 21 years of age). Risk of measles during an outbreak associated with age at first measles vaccination, length of time since vaccination, vaccination before 1980 and whether date of vaccination was estimated; vaccine efficacy of one dose versus two doses. Eighty-seven laboratory-confirmed or clinically confirmed cases of measles were identified (for an attack rate of 7.7%). The measles vaccination rate was 94.2%, and 10% of the students had received two doses of measles vaccine before the outbreak. Among those who had received only one dose of vaccine, vaccination at less than 15 months of age was associated with vaccine failure (relative risk 3.62, 95% confidence interval 2.32 to 5.66). There was no increased risk of vaccine failure associated with length of time since vaccination once the relative risk was adjusted for age at vaccination in a stratified analysis. Vaccination before 1980 and an estimated date of vaccination were not associated with increased...Continue Reading

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