Outbreak of thiamine deficiency in cats associated with the feeding of defective dry food

Journal of Feline Medicine and Surgery
Ya-Pei ChangChen-Hsuan Liu

Abstract

Objectives The objective of this study was to determine disease progression, association between neurological signs and magnetic resonance imaging (MRI) findings, and long-term outcome in feline thiamine deficiency associated with defective dry food. Methods The clinical records of 17 cats diagnosed with thiamine deficiency related to a defective dry food were examined and data collected. The thiamine level in the food was analysed by liquid chromatography-tandem mass spectrometry. Results The thiamine level in the food was below the recommendation of the National Research Council. Fifteen cats were fed the food exclusively. Prior to the acute development of neurological signs, most cats displayed non-specific signs such as anorexia, lethargy or vomiting. Vestibular signs of varying severity were observed in 94% of the cats, and all but one of these presented with bilateral dysfunction. Other main neurological signs included altered mentation (76%), blindness (59%) and seizures (59%). Moreover, 80% of the cats with seizures presented with cluster seizures or status epilepticus. MRI abnormalities consistent with findings reported in the previous literature were detected in five cases. MRI was unremarkable in one cat with ongoing...Continue Reading

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Citations

Aug 25, 2018·Journal of Feline Medicine and Surgery·Michal Hazenfratz, Susan M Taylor
Nov 27, 2019·Current Opinion in Neurology·Jorge C Kattah, David S Zee
May 1, 2019·Journal of the American Veterinary Medical Association·Sarah A WilsonJennifer A Larsen
Nov 13, 2020·Journal of Feline Medicine and Surgery·Nicholas J GrapesSteven De Decker
Mar 4, 2021·Journal of Animal Physiology and Animal Nutrition·Marco FantinatiNathalie Priymenko

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