Outbreaks of gastroenteritis in elderly nursing homes and retirement facilities associated with human caliciviruses

Journal of Medical Virology
X JiangD O Matson

Abstract

Eleven outbreaks of acute gastroenteritis, eight of which were in nursing homes or retirement facilities, were reported in virginia during the winter of 1993-1994. Serum samples (four outbreaks) and stool samples (two outbreaks) from involved people were tested for human calicivirus (HuCV) infection by enzyme immune assays (EIAs) using recombinant Norwalk virus (rNV) and Mexico virus (rMX) capsid antigens and reverse transcription-polymerase chain reaction (RT-PCR). Of the 31 pairs of acute and convalescent serum specimens tested, 24 had a fourfold or more titer increase to rMX and 4 responded to rNV. In all four outbreaks, the geometric mean titers (GMTs) against rMX were significantly higher than those against rNV in the convalescent, but not in the acute phase of illness. The antibody response to rMX among these patients was also higher than to rNV (summary mean 32-fold increase vs. 0.7-fold increase, respectively, P < .001). Antigen was detected in 5 of 21 stool specimens tested by the rMX EIA, RNA in 12 of 17 stool specimens tested by RT-PCR, and small round structured virus (SRSV) particles in 12 of 21 by electron microscopy (EM); none were positive by the rNV EIA. Sequence analysis of the RT-PCR-amplified products from t...Continue Reading

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Citations

Mar 20, 2003·Emerging Infectious Diseases·Paul R Hazelton, Hans R Gelderblom
Apr 9, 2004·Journal of Clinical Microbiology·Chris I GallimoreDavid W G Brown
Feb 19, 2010·BMC Infectious Diseases·Maria WadlHelen Bernard
May 7, 2010·Journal of Clinical Microbiology·Jacqueline XerryJim J Gray
May 11, 2000·The Journal of Infectious Diseases·X JiangD O Matson
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ben A LopmanDavid W G Brown
Apr 9, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Miren Iturriza-GómaraJim Gray
Oct 10, 2007·Clinics in Geriatric Medicine·Chantri Trinh, Kavita Prabhakar
Oct 8, 2008·Immunological Reviews·Eric F DonaldsonRalph S Baric
Oct 21, 2011·Journal of Medical Virology·James AyukekbongTomas Bergström
Jun 22, 2005·International Journal of Food Microbiology·Chris I GallimoreJim J Gray
Feb 7, 2015·Journal of Medical Virology·Noelia Carmona-VicenteJavier Buesa
Feb 4, 2010·Nature Reviews. Microbiology·Eric F DonaldsonRalph S Baric
Jul 12, 2007·Expert Reviews in Molecular Medicine·Ming Tan, Xi Jiang
Aug 24, 2007·Clinical and Vaccine Immunology : CVI·Jim J GraySabine M Diedrich
May 4, 2004·Scandinavian Journal of Infectious Diseases·Abu S G FaruqueDavid A Sack
Aug 18, 2000·International Journal of Food Microbiology·D Lees

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