Outcome according to subspecies following lung transplantation in cystic fibrosis pediatric patients infected with Mycobacterium abscessus.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
Ema KavaliunaiteHelen Spencer

Abstract

Mycobacterium abscessus infection has been associated with variable outcomes following lung transplantation. M abscessus comprises three subspecies (M abscessus subsp abscessus, M abscessus subsp massiliense, and M abscessus subsp bolletii). We investigated whether lung transplantation outcome in cystic fibrosis (CF) patients in a single center was related to the M abscessus subspecies and genetic cluster. CF patients with chronic M abscessus infection transplanted at Great Ormond Street Hospital between 2004 and 2017 were retrospectively examined. All M abscessus isolates were identified to subspecies level by polymerase chain reaction and sequencing. Genetic cluster was determined by variable number tandem repeat profiling and whole-genome sequencing (WGS), and sequence type inferred from WGS. Thirteen patients with chronic M abscessus infection underwent heart/lung or lung transplantation. Subspecies identification showed n = 1 with M abscessus bolletii, n = 5 with M abscessus massiliense, and n = 7 with M abscessus abscessus infection. Eight (62%) patients (one with M abscessus massiliense and seven with M abscessus abscessus) died post-lung transplant. The patient with M abscessus bolletii and three patients with M abscess...Continue Reading

References

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Jan 1, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Daan RaatsLieven Dupont
Jan 29, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liam P ShawKathryn A Harris
Jun 22, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ronan M DoyleKathryn A Harris

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Citations

Mar 13, 2021·Microbiology Resource Announcements·Elizabeth D AmarhGraham F Hatfull
May 1, 2021·Science·Rossa Brugha, Helen Spencer
Feb 6, 2021·The European Respiratory Journal·Dominic A HughesSiobhán B Carr

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