Abstract
The objective of this study is to assess the outcome after pharyngeal reconstruction using pectoralis major and radial forearm flaps in pharyngeal and laryngeal carcinomas. 90 patients who underwent flap surgery due to oro/-hypopharyngeal and laryngeal carcinomas were compared with 404 patients without pharyngeal reconstruction. Differences between the groups were analyzed using the Chi-square, Fisher exact, and the unpaired student's t test. Survival rates were calculated by Kaplan-Meier. Overall survival in oropharyngeal and hypopharyngeal/laryngeal cancer showed comparable results in patients with or without pharyngeal reconstruction (5-year: 53.4 vs. 64.2 %, p = 0.23; 5-year: 51.8 vs. 62.4 %, p = 0.94), while the survival time after flap surgery was significantly decreased (5-year: 44.8 vs. 62.4 %, p < 0.02; 5-year: 30.3 vs. 64.2 %, p = 0.07). Subgroup analysis attributed the worse survival after flap surgery to patients who underwent flap surgery due to functional deficits or recurrent disease (p = 0.002). In these patients, the median survival after flap surgery was 26 (hypopharyngeal/laryngeal cancer) or 13 months (oropharyngeal cancer) and associated with a significant increase in severe complications and hospitalizatio...Continue Reading
References
Jan 1, 1979·Plastic and Reconstructive Surgery·S Ariyan
Apr 1, 1976·British Journal of Plastic Surgery·N Olivari
Jun 1, 1984·Annals of Plastic Surgery·J KatsarosR D Acland
Apr 1, 1997·British Journal of Plastic Surgery·G F YangS P He
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Jul 5, 2005·The Laryngoscope·Jan S LewinPeirong Yu
Sep 20, 2006·Head & Neck·Ian GanlyDennis H Kraus
Oct 6, 2006·Head & Neck·Dylan J MurrayPeter C Neligan
Oct 21, 2009·Archives of Otolaryngology--head & Neck Surgery·Ziv GilSnehal G Patel
May 28, 2011·Head & Neck Oncology·Isaac A BohannonEben L Rosenthal
Jun 8, 2012·The Laryngoscope·Kiran KakaralaDaniel G Deschler
May 21, 2013·The Laryngoscope·John W FrederickEben L Rosenthal
Jun 8, 2013·HNO·S Herberhold, F Bootz
Mar 13, 2014·Clinics in Plastic Surgery·Michael S Gart, Arun K Gosain
Mar 19, 2014·HNO·A KnopfE Scherer
Jul 16, 2014·Journal of Reconstructive Microsurgery·Prabhat K BhamaNeal D Futran
Aug 19, 2014·The Laryngoscope·Mark R GilbertSeungwon Kim
Nov 29, 2014·Microsurgery·Ngian Chye TanYur-Ren Kuo
Jan 13, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Cuneyt KucurEnver Ozer
Jan 21, 2015·International Journal of Surgery·Bo KongJörg Kleeff
Jan 30, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sidharth V PuramDaniel G Deschler
Mar 5, 2015·Oncotarget·Christian JacobiAndreas Knopf
Citations
Oct 17, 2012·Oral Oncology·S A H J de VisscherM J H Witjes
Feb 13, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·M C KettererC Becker
Jan 20, 2018·Oncotarget·Andreas KnopfYin Li