Outcome after PSMA PET/CT based salvage radiotherapy in patients with biochemical recurrence after radical prostatectomy: a bi-institutional retrospective analysis

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Nina-Sophie Schmidt-HegemannConstantinos Zamboglou

Abstract

Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) detects prostate cancer recurrence at low PSA levels. Radiotherapy with dose escalation to the former prostate bed has been associated with improved biochemical recurrence-free survival (BRFS). Thus, we hypothesized that PSMA PET/CT-guided salvage radiotherapy leads to improved BRFS. Methods: A total of 204 consecutive patients were referred for salvage radiotherapy following radical prostatectomy. PSMA PET/CT scans were performed and patients with PSA persistence (109 patients) or evidence of distant metastases (5 patients) were excluded from this analysis. Thus, the following analysis is based on a total of 90 patients who underwent PSMA PET/CT prior to radiotherapy due to biochemical recurrence and received salvage radiotherapy. In case of PET-positive findings, antiandrogen therapy was commenced before initiation of radiotherapy. BRFS (PSA ≤ 0.2 ng/ml) was defined as the study endpoint. Results: PET-positive lesions were detected in 42/90 (47%) patients: 24/42 (27%) fossa recurrence only, 12/42 (13%) pelvic lymph nodes only and 6/42 (7%) fossa and pelvic lymph node recurrence. Median PSA before radiotherapy was 0.44 (0.11 - 6.2...Continue Reading

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Citations

Sep 8, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Francesco CeciStefano Fanti
Jul 6, 2019·Clinical Nuclear Medicine·Maurits WondergemRemco J J Knol
Jul 1, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G FrancoliniG Ingrosso
Apr 23, 2020·Radiation Oncology·M UnterrainerC Belka
Jan 6, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Elisa PerryTom R Sutherland
Mar 10, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Özgül EkmekciogluFred Verzijlbergen
Apr 14, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Etienne RousseauFrançois Bénard
Jan 29, 2022·Current Medical Science·Jun LiuRong Shi

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