Outcome after surgical resection for duodenal adenocarcinoma in the UK

The British Journal of Surgery
L SolainiUK Duodenal Cancer Study Group

Abstract

Factors influencing long-term outcome after surgical resection for duodenal adenocarcinoma are unclear. A prospectively created database was reviewed for patients undergoing surgery for duodenal adenocarcinoma in six UK hepatopancreaticobiliary centres from 2000 to 2013. Factors influencing overall survival and disease-free survival (DFS) were identified by regression analysis. Resection with curative intent was performed in 150 (84·3 per cent) of 178 patients. The postoperative morbidity rate for these patients was 40·0 per cent and the in-hospital mortality rate was 3·3 per cent. Patients who underwent resection had a better median survival than those who had a palliative surgical procedure (84 versus 8 months; P < 0·001). The 1-, 3- and 5-year overall survival rates for patients who underwent resection were 83·9, 66·7 and 51·2 per cent respectively. Median DFS was 53 months, and 1- and 3-year DFS rates were 80·8 and 56·5 per cent respectively. Multivariable analysis revealed that node status (hazard ratio 1·73, 95 per cent c.i. 1·07 to 2·79; P = 0·006) and lymphovascular invasion (hazard ratio 3·49, 1·83 to 6·64; P = 0·003) were associated with overall survival. Resection of duodenal adenocarcinoma in specialist centres is a...Continue Reading

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Citations

Apr 10, 2016·Surgery·E Madelief MarsmanUNKNOWN Dutch Pancreatic Cancer Group
Mar 30, 2016·World Journal of Gastrointestinal Surgery·Jordan M CloydBrendan C Visser
Jan 30, 2020·Khirurgiia·G A ShatveryanG A Karagyozyan
Jun 28, 2018·Annals of Surgical Oncology·Laura L MeijerGeert Kazemier
Jun 30, 2018·Digestive Diseases and Sciences·Chihiro MinatsukiKazuhiko Koike
May 6, 2020·Annals of Surgical Oncology·Nobuhito NittaKatsuhiko Uesaka
Mar 25, 2020·World Journal of Gastrointestinal Oncology·Laura L MeijerGeert Kazemier
Aug 12, 2017·Annals of Surgical Oncology·Taro SakamotoHiromichi Ito
Jan 3, 2021·International Journal of Clinical Oncology·Pipit BurasakarnUNKNOWN Japan Duodenal Cancer Guideline Committee
Sep 30, 2019·Cirugía española·Josefina López-DomínguezJuan Fabregat
Oct 31, 2020·Journal of Surgical Oncology·Toms AugustinRichard Matthew Walsh
May 21, 2021·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jana TesarikovaMartin Lovecek

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