Outcome After Therapeutic Hypothermia in Term Neonates With Encephalopathy and a Syndromic Diagnosis

Journal of Child Neurology
Anna MrelashviliHannah C Glass

Abstract

The large randomized, controlled trials of therapeutic hypothermia for hypoxic-ischemic encephalopathy excluded neonates with congenital disorders. The objective of this study was to report our experience using hypothermia in neonates with signs of hypoxic-ischemic encephalopathy and a syndromic disorder or brain anomaly. Subjects were identified from a database of neonates admitted to the Neuro-Intensive Care Nursery at University of California, San Francisco. Of 169 patients fulfilling criteria for hypothermia, 8 (5%) had a syndromic disorder and were cooled per guidelines for nonsyndromic neonates. Perinatal characteristics of infants with and without syndromic disorder were not significantly different. Overall outcome was poor: 38% had evidence of acute hypoxic-ischemic injury, 3 subjects died, and 2 survivors had low developmental quotient (ie, 25). The risk versus benefit of therapeutic hypothermia for hypoxic-ischemic encephalopathy among neonates with congenital brain malformations or syndromic diagnoses is uncertain.

References

Dec 4, 1998·BMJ : British Medical Journal·N BadawiF J Stanley
Oct 14, 2005·The New England Journal of Medicine·Seetha ShankaranUNKNOWN National Institute of Child Health and Human Development Neonatal Research Network
Jun 4, 2008·The Journal of Comparative Neurology·Juan SuárezFernando Rodríguez de Fonseca
Nov 28, 2012·Developmental Medicine and Child Neurology·Sarah McIntyreEve Blair
Oct 3, 2013·Obstetrics and Gynecology·Sarah McIntyreKarin B Nelson

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Citations

Aug 16, 2016·Clinics in Perinatology·Hannah C Glass, David H Rowitch
Feb 13, 2018·Continuum : Lifelong Learning in Neurology·Hannah C Glass

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