Outcome analysis of patients with pN2 oral cavity cancer

Annals of Surgical Oncology
Chun-Ta LiaoTzu-Chen Yen

Abstract

The American Joint Committee on Cancer staging system suggests that squamous-cell carcinoma of the oral cavity (OSCC) with pN2 should be classified as stage IVA. The objective of the current study was to determine the outcome of patients with pN2 OSCC cancer according to different T status. Between January 1996 and September 2007, a total of 270 patients with pN2 OSCC cancer were analyzed. All participants had a follow-up of at least 2 years or were censored on the date of last follow-up. The outcome measures for this study were the 5-year rates of locoregional control, distant metastases, and survival. Five-year disease-specific survival and overall survival rates in pT1 (n = 9), pT2 (n = 98), pT3 (n = 70), and pT4 (n = 93) patients were 78%, 66%, 49%, 35% (P = 0.0031), and 78%, 52%, 35%, 23% (P = 0.0001), respectively. Multivariable analysis revealed that pT3-4, level IV/V metastases, extracapsular spread, and poor differentiation were independent risk factors for 5-year disease-specific survival in the entire study cohort. Specific independent prognostic factors for 5-year disease-specific survival according to T stage were found. The results of this study suggest that patients with pN2 OSCC cancer have different outcomes an...Continue Reading

References

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Citations

Aug 7, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Chung-Guei HuangTzu-Chen Yen
Jun 1, 2011·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Danielle Resende CamisascaSimone de Queiroz Chaves Lourenço
Jun 25, 2013·The British Journal of Oral & Maxillofacial Surgery·Tommaso CutilliEmma Altobelli
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·Chun-Ta LiaoTzu-Chen Yen

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