Outcome and comparator choice in molar incisor hypomineralisation (MIH) intervention studies: a systematic review and social network analysis

BMJ Open
Karim ElhennawyFalk Schwendicke

Abstract

Outcome and comparator choice strongly determine the validity and implementation of clinical trial results. We aimed to assess outcome and comparator choice in intervention studies on molar incisor hypomineralisation (MIH) using systematic review and social network analysis (SNA). Medline, Embase, Cochrane Central, Google Scholar, opengrey.eu as well as DRKS.de and Clinicaltrials.gov were searched for MIH intervention studies. The search covered the period from 1980 to 2019. Clinical single-arm/multiarm, controlled/uncontrolled studies reporting on the management of MIH were included. Reported outcomes and comparators were extracted and categorised. SNA was used to evaluate comparator choice and the resulting trial networks. Of the 7979 identified records, 100 were evaluated in full text and 35 studies (17 randomised controlled trials, 14 prospective and 4 retrospective cohort studies) were included. In total, 2124 patients with a mean age of 11 years (min/max 6/70 years) were included. Outcomes fell in one of 11 different outcome categories: restoration success, aesthetic improvement, pain/hypersensitivity/discomfort, mineral gain, space management, anaesthesia effectiveness, preventive success, efficiency, quality of life, gi...Continue Reading

Citations

Oct 11, 2020·British Dental Journal·Reem AlkhalafMarie Therese Hosey
Feb 2, 2021·Acta Odontologica Scandinavica·Luísa Bandeira LopesDorte Haubek
Jun 11, 2021·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·C SomaniF S L Wong
Jun 11, 2021·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·B JälevikA Robertson
Oct 21, 2021·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·N A LygidakisF S L Wong

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Methods Mentioned

BETA
X-ray

Clinical Trials Mentioned

NCT03614819
NCT03760497
NCT03826810
NCT03870958
NCT03862014

Software Mentioned

Cochrane
SNA
Google Scholar

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