Outcome and its predictors in Guillain-Barre syndrome

Journal of Neurology, Neurosurgery, and Psychiatry
Yusuf A Rajabally, Antonino Uncini

Abstract

Despite the use of plasma exchanges and intravenous immunoglobulins, Guillain-Barré syndrome (GBS) still carries non-negligible morbidity and mortality. Furthermore, the psychosocial consequences of GBS may persist longer than expected. Various aetiological, clinical, electrophysiological and immunological factors may carry prognostic predictive value. The objective of this article was to perform a summary of the current knowledge-base on outcome and its determinants in adequately-treated adult-onset GBS. Relevant prospective literature was reviewed through a Medline search of English-language articles published between 1966 and March 2012. GBS causes severe persistent disability in 14% of patients at 1 year. Loss of full strength, persistent pain and need for professional change occurs in about 40%. Mortality is of about 4% within the first year. Analysis of prognostic predictors consistently demonstrates the negative impact of higher age, preceding diarrhoea, greater disability/weaker muscles at admission, short interval between symptom-onset and admission, mechanical ventilation and absent/low amplitude compound muscle action potentials. Further outcome studies will soon be underway and may in future contribute to adequately...Continue Reading

Citations

Feb 2, 2013·Journal of Neurology·María J SedanoJosé Berciano
Jun 25, 2013·Trends in Pharmacological Sciences·Mathias ButtmannHans-Peter Hartung
Jul 3, 2013·The Lancet Infectious Diseases·Lucija Tomljenovic, Yehuda Shoenfeld
Dec 3, 2013·Rinshō shinkeigaku = Clinical neurology·Kenichi Kaida
Sep 4, 2015·The International Journal of Neuroscience·Elena RuizEva Martínez-Ochoa
Sep 28, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zhi-Ming ZhangZhiren Zhang
Jan 3, 2016·Clinical Neurology and Neurosurgery·Elisabeth FarbuSigurbjørg Stefansdottir
Apr 30, 2013·Lancet·Gregory A PolandCharles L Howe
Jun 21, 2013·Journal of the Peripheral Nervous System : JPNS·Simon Rinaldi
Jan 25, 2014·Journal of the Peripheral Nervous System : JPNS·Jayantee KalitaMoromi Das
Sep 10, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J O T Sipilä, M Soilu-Hänninen
Nov 19, 2014·Journal of the Peripheral Nervous System : JPNS·Loïc Le GuennecNicolas Weiss
Oct 30, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J S BaeJ K Kim
Mar 15, 2016·The International Journal of Neuroscience·Jussi O T SipiläMerja Soilu-Hänninen
Jan 15, 2015·Journal of the Peripheral Nervous System : JPNS·Stojan PericDragana Lavrnic
Dec 30, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jui-Hsiang LinMing-Yang Chang
Mar 6, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Satoshi NagamineTomohiro Kabuta
Dec 30, 2014·Neurología : publicación oficial de la Sociedad Española de Neurología·P GonzálezO Hernández
Feb 18, 2016·Journal of the Peripheral Nervous System : JPNS·Stojan PericDragana Lavrnic
Mar 8, 2016·Lancet·Hugh J WillisonPieter A van Doorn
Jul 28, 2016·Korean journal of pediatrics·Eung-Bin LeeSae Yoon Kim
Sep 15, 2016·Neurology India·Madhu NagappaShivaji Rao
Aug 2, 2016·Journal of the Peripheral Nervous System : JPNS·Gonzalo Rivera-LilloMauricio Hernández
Apr 4, 2017·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Primož NovakGaj Vidmar
Feb 9, 2017·Journal of the Peripheral Nervous System : JPNS·Stojan PericZorica Stevic
Apr 28, 2017·Journal of the Peripheral Nervous System : JPNS·Tanveen IshaqueZhahirul Islam
Sep 10, 2014·Clinical Rehabilitation·Anette ForsbergGerd Ahlström
Jan 20, 2018·Case Reports in Transplantation·Massini MerzkaniMala Sachdeva
Dec 1, 2017·Journal of Clinical Neuromuscular Disease·Kongkiat Kulkantrakorn, Puchit Sukphulloprat
Dec 10, 2015·British Journal of Hospital Medicine·Catherine Morgan, Benjamin Wakerley
May 15, 2018·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Vesna MarticZorica Stevic
Jul 19, 2018·Acta Neurologica Scandinavica·Brynhildur HafsteinsdóttirFinnbogi Jakobsson
Apr 9, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Bianca van den BergBart C Jacobs
Jul 20, 2017·The American Journal of Tropical Medicine and Hygiene·Stephanie BalavoineKinda Schepers
Sep 23, 2014·The Cochrane Database of Systematic Reviews·Richard A C HughesPieter A van Doorn
Apr 3, 2020·Rinshō shinkeigaku = Clinical neurology·Yuko Yamagishi, Susumu Kusunoki
Mar 9, 2019·Annals of Clinical and Translational Neurology·Zhahirul IslamQuazi D Mohammad
Mar 30, 2019·Infectious Diseases in Clinical Practice : IDCP·Jason BeattieAnna Nolan
Jul 8, 2020·Neurology. Neuroimmunology and Neuroinflammation·Aline de Moura Brasil MatosCamila Malta Romano
Jun 27, 2020·AJNR. American Journal of Neuroradiology·K L HutchinsN A Koontz

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