PMID: 9163615May 1, 1997Paper

Outcome and lineage involvement in t(12;21) childhood acute lymphoblastic leukaemia

British Journal of Haematology
C LanzaG Saglio

Abstract

The t(12;21)(p13;q22) translocation has been described recently as the most recurrent genetic lesion in paediatric acute lymphoblastic leukaemias (ALLs). It has also been associated with B-precursor lineage involvement and good outcome. We tested 51 diagnostic paediatric ALLs and found 11 cases with molecular evidence of the t(12;21). Interestingly, amongst t(12;21) positive patients, we report three cases with hybrid phenotype, and two cases showing an aggressive and fatal disease. Our data show that the t(12;21) does not represent an independent good-risk indicator. Long follow-ups and additional molecular investigations are needed to assess the prognostic and pathogenetic relevance of t(12;21) in childhood ALLs.

Citations

Apr 24, 2004·Cancer Genetics and Cytogenetics·Pornthep Tiensiwakul
Jun 4, 2002·Current Opinion in Hematology·Mignon L Loh, Jeffrey E Rubnitz
Dec 14, 2005·Journal of Pediatric Hematology/oncology·Stefanos I PapadhimitriouF Athanassiadou
Apr 14, 2010·Journal of Pediatric Hematology/oncology·Mariam Faiz, Javed Iqbal Qazi
Sep 25, 2007·Cancer Genetics and Cytogenetics·Yi-Jin GaoHong-Sheng Wang
Feb 5, 2008·British Journal of Haematology·Erik ForestierUNKNOWN NOPHO Leukaemia Cytogenetic Study Group (NLCSG)
May 4, 2004·Cancer Genetics and Cytogenetics·P R G ZenG A Paskulin
Jun 28, 2003·Pediatrics International : Official Journal of the Japan Pediatric Society·Chie EndoYoshiki Seino
Feb 8, 2007·Genes, Chromosomes & Cancer·Erik ForestierUNKNOWN NOPHO Leukemia Cytogenetic Study Group (NLCSG)

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