Outcome and management of newborns with congenital cytomegalovirus infection

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
M NiclouxJ-F Magny

Abstract

Congenital cytomegalovirus (CMV) infection is the most common non-genetic cause of hearing loss and neurological disorder in children. Its overall prevalence is approximately 0.5% in Europe. In France, systematic screening during pregnancy is not recommended; screening is performed only if there are maternal or fetal symptoms suggestive of this infection. Approximately 90% of infected newborns are asymptomatic at birth, and among them the risk of neurosensory sequelae is 5-15%. By contrast, the prevalence of neurosensory impairment in symptomatic newborns at birth varies from 17% to 60%. Congenital CMV infection must be confirmed at birth before the 21st day of life by polymerase chain reaction (PCR) on saliva or urine samples. A complete clinical examination, blood tests (blood count, liver function test, CMV PCR), hearing tests, brain ultrasound and eye fundus examination should be performed. Neurological and auditory follow-up must be extended well beyond the neonatal period because the occurrence of neurosensory sequelae may be delayed. Oral valganciclovir is the recommended treatment in moderate or severe congenital CMV infections for a period of 6 weeks to 6 months; such treatment requires regular monitoring because of it...Continue Reading

Citations

May 4, 2021·Frontiers in Microbiology·Wenwen XiaZhijun Liu
Aug 7, 2021·Clinics in Perinatology·Tina A Leone, Wanda J Abreu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
Fernando Baquero-Artigao, Grupo de estudio de la infección congénita por citomegalovirus de la Sociedad Española de Infectología Pediátrica
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Wen-Fang Xu, Tian-Ming Yuan
Zeitschrift für Geburtshilfe und Neonatologie
Christoph Bührerfür die Screeningkommission der Deutschen Gesellschaft für Kinder- und Jugendmedizin (Mitglieder am Ende des Artikels)
© 2021 Meta ULC. All rights reserved