Outcome and risk of recurrence for endoscopic resection of colonic superficial neoplastic lesions over 2 cm in diameter

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Giovanna MargagnoniEmilio Di Giulio

Abstract

Large colorectal superficial neoplastic lesions are challenging to remove. This study aimed to assess the outcomes of routine endoscopic resection of large (≥2 cm and <3 cm) and giant (≥3 cm) lesions. From 4587 endoscopic resections, 265 (5.7%) large and giant lesions were removed in 249 patients. We retrospectively analyzed 125 patients (141 endoscopic mucosal resection, 73 large and 68 giant lesions) with a follow-up of 6-12 months. Rate of en bloc and piecemeal resection, recurrence and risk factors were analyzed. En bloc was performed in 92 cases (65.2%) and piecemeal resection in 49 (34.8%). A complete endoscopic resection was achieved in 139 cases (98.5%) with radical resection in 84/139 cases (60.4%). Argon plasma coagulation was applied in 18/141 lesions (12.8%). A recurrence occurred in 16/139 lesions (11.5%). The risk of recurrence at one year was significantly higher for giant than large lesions (p=0.03). The recurrence risk was higher in treated than in non-argon plasma coagulation treated lesions (p=0.01). endoscopic mucosal resection is a safe and effective routine treatment for large superficial neoplastic lesions. The risk factors for recurrence include giant size, non-protruding morphology, piecemeal technique ...Continue Reading

References

Nov 1, 1994·Diseases of the Colon and Rectum·T YokotaS Yoshida
Dec 30, 1993·The New England Journal of Medicine·S J WinawerJ F Panish
Mar 1, 1996·Gastrointestinal Endoscopy·K F BinmoellerN Soehendra
Nov 25, 2003·ANZ Journal of Surgery·James M Church
Dec 3, 2003·The New England Journal of Medicine·John D BirkmeyerF Lee Lucas
Jul 28, 2004·Gastrointestinal Endoscopy·Massimo ConioRosangela Filiberti
Dec 2, 2005·Current Opinion in Gastroenterology·Norio Fukami, Jeffrey H Lee
Mar 28, 2006·Gastrointestinal Endoscopy·Stefan Seewald, Nib Soehendra
Jan 27, 2007·Digestive Diseases and Sciences·Jaume BoixMiquel A Gassull
Jun 5, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Douglas K Rex
Jun 15, 2007·Scandinavian Journal of Gastroenterology·Naila ArebiBrian P Saunders
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jul 21, 2009·Diseases of the Colon and Rectum·Alessandro RepiciAlberto Malesci
Feb 2, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayE Steliarova-Foucher
Feb 18, 2011·Digestive Diseases and Sciences·J MannathK Ragunath

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Citations

Jun 26, 2017·Gastrointestinal Endoscopy·Qisheng ZhangYucui Shen
Nov 7, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·L MlynarskyR Kariv
Dec 11, 2019·Scandinavian Journal of Gastroenterology·Dalila CostaCarla Rolanda

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