Outcome and toxicity analysis of single dose stereotactic radiosurgery in vestibular schwannoma based on the Koos grading system.

Scientific Reports
Daniel RueßMaximillian Ruge

Abstract

Stereotactic radiosurgery (SRS) has evolved as widely accepted treatment option for small-sized (Koos I up to II) vestibular schwannoma (VS). For larger tumors (prevalent Koos VI), microsurgery or combined treatment strategies are mostly recommended. However, in patients not suited for microsurgery, SRS might also be an alternative to balance tumor control, hearing preservation and adverse effects. The purpose of this analysis was to evaluate the efficacy and toxicity of SRS for VS with regard to different Koos grades. All patients with untreated VS who received SRS at our center were included. Outcome analysis included tumor control, preservation of serviceable hearing based on median pure tone averages (PTA), and procedure-related adverse events rated by the Common Terminology Criteria for Adverse Events (CTCAE; v4.03) classification. In total, 258 patients (median age 58 years, range 21-84) were identified with a mean follow-up of 52 months (range 3-228 months). Mean tumor volume was 1.8 ml (range 0.1-18.5). The mean marginal dose was 12.3 Gy ± 0.6 (range 11-13.5). The cohort was divided into two groups: A (Koos grades I and II, n = 186) and B (Koos grades III and IV, n = 72). The actuarial tumor control rate was 98% after 2...Continue Reading

References

Jan 1, 1988·The Annals of Otology, Rhinology, and Laryngology·G Gardner, J H Robertson
Jan 1, 1995·Archives of Neurology·O K OgunrindeD S Kondziolka
Nov 27, 2002·Journal of Neurosurgery·Jean RégisJean Claude Peragut
Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Charlie C PanPaul R Kileny
Jan 7, 2006·Journal of Neuro-oncology·Chul-Kee ParkDong Gyu Kim
Sep 7, 2006·British Journal of Neurosurgery·R S WeilM Brada
Jan 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Niranjan BhandareWilliam M Mendenhall
Mar 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Rahul ChopraJohn C Flickinger
Sep 24, 2008·Progress in Neurological Surgery·Ajay NiranjanL Dade Lunsford
Dec 6, 2008·Neurosurgery·Ajay NiranjanL Dade Lunsford
May 12, 2009·Journal of Neuro-oncology·Isaac YangAndrew T Parsa
Aug 12, 2009·Journal of Neurosurgery·Madjid SamiiAmir Samii
Dec 1, 2009·Journal of Neurosurgery·Michael E SughrueAndrew T Parsa
Mar 17, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Peng-Wei HsuKuo-Cheng Wei
Jul 16, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Michael E SughrueAndrew T Parsa
Aug 31, 2010·Journal of Neurosurgery·Huai-Che YangDouglas Kondziolka
Sep 28, 2010·Neurosurgery·Sven-Eric StangerupPer Caye-Thomasen
Dec 9, 2010·Journal of Neurosurgery·Wen-Yuh ChungYang-Hsin Shih
Jul 22, 2011·Deutsches Ärzteblatt International·Thomas Zahnert
Oct 8, 2013·Neurosurgery Clinics of North America·Jean RégisPierre-Hugues Roche
Dec 7, 2013·BioMed Research International·Jo-Ting TsaiDa-Tong Ju
Sep 3, 2014·Neurosurgery·Amjad N AnaiziPhilip V Theodosopoulos
Dec 3, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Takayuki MatsuoIzumi Nagata
Aug 19, 2015·Clinical Neurology and Neurosurgery·Daphne LiAnand V Germanwala
Apr 22, 2017·Radiation Oncology·Daniel RueßMaximilian I Ruge
Jul 15, 2017·Journal of Neurosurgery·Cheng-Wei HuangChuan-Fu Huang
May 2, 2018·World Neurosurgery·Daniel RueßMaximilian I Ruge
Jan 16, 2020·Curēus·Paul Y WindischAlexander Muacevic

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

STP
Graphpad PRZM
SPSS

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.