Outcome-based interpretation of early interim PET in advanced-stage Hodgkin lymphoma.

Blood
Carsten KobeMarkus Dietlein

Abstract

The HD18 study for patients with newly diagnosed advanced-stage Hodgkin lymphoma (HL) used positron emission tomography (PET) after 2 cycles (PET-2) of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone in escalated doses (eBEACOPP) to guide further treatment. Here, we analyzed the impact of PET-2 results in the context of eBEACOPP according to the Deauville score (DS) in patients treated within the HD18 trial. Residual tissue was visually compared with reference regions according to DS. We analyzed the association between PET-2 uptake and baseline characteristics, progression-free survival (PFS), and overall survival (OS). One thousand five patients (52%) had DS1 or DS2, 471 (24%) had DS3, and 469 (24%) DS4. PET-2 uptake was associated with baseline risk factors large mediastinal mass, extranodal disease, and high International Prognostic Score (P < .0001 each). Among 722 patients receiving standard therapy with 6 cycles of eBEACOPP, 3-year PFS rates were 92.2%, 95.9%, and 87.6% with DS1-2, DS3, and DS4, respectively. Univariate hazard ratio (HR) for PFS in patients with DS4 vs DS1-3 was 2.3 (1.3-3.8; P = .002). DS4 was the only factor remaining significant for PFS in a multivariate ...Continue Reading

Associated Clinical Trials

Aug 13, 2007·Prof. Dr. Andreas Engert

References

Nov 19, 1992·The New England Journal of Medicine·G P CanellosB A Peterson
Jun 13, 2003·The New England Journal of Medicine·Volker DiehlUNKNOWN German Hodgkin's Lymphoma Study Group
Jan 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Massimo FedericoUNKNOWN HD2000 Gruppo Italiano per lo Studio dei Linfomi Trial
Jun 23, 2009·Leukemia & Lymphoma·Michel MeignanCorinne Haioun
Oct 23, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C FurthC Kobe
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonT Andrew Lister
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sally F BarringtonBruce D Cheson
Apr 23, 2015·The New England Journal of Medicine·John RadfordSally Barrington
Apr 14, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Oliver W PressJonathan W Friedberg
Jun 23, 2016·The New England Journal of Medicine·Peter JohnsonSally Barrington
Mar 16, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc P E AndréJohn Raemaekers
Apr 16, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Sally F Barrington, Regine Kluge
Dec 3, 2017·Seminars in Nuclear Medicine·Tarec Christoffer El-GalalyMartin Hutchings

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Citations

Oct 1, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carsten KobePeter Borchmann
Mar 11, 2020·Cancers·Conrad-Amadeus VoltinDirk Hellwig
Jun 6, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Richard T HoppeNdiya Ogba
Nov 16, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Egesta Lopci, Michel Meignan
Jun 17, 2020·Therapeutic Advances in Hematology·Noemie Lang, Michael Crump
Jul 25, 2020·Nature Reviews. Disease Primers·Joseph M ConnorsNancy L Bartlett
Oct 28, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stefano LuminariAlessia Ciarrocchi
Jan 18, 2020·The Lancet. Haematology·Anthony J Perissinotti
Apr 8, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sally F Barrington, Michel Meignan
Dec 29, 2020·The Lancet. Haematology·Judith Trotman, Sally F Barrington
Jan 7, 2022·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·René-Olivier CasasnovasCédric Rossi
Jan 18, 2022·British Journal of Haematology·Tarec Christoffer El-GalalyLars C Gormsen

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