Outcome following, and impact of, prenatal identification of the candidates for the Norwood procedure

Cardiology in the Young
Robin R Fountain-DommerGirish S Shirali

Abstract

Our study evaluates hospital survival following prenatal identification of candidates for the Norwood procedure, and the impact of prenatal diagnosis on survival, preoperative stability, and postoperative morbidity. We reviewed records of all patients who were identified prenatally as candidates for the Norwood procedure, and compared them to all postnatally diagnosed patients who underwent the Norwood procedure between August 1995 and May 2002. Of the 98 patients studied, 45 (46%) were diagnosed prenatally. Of these, 35 underwent the Norwood procedure, 29 (83%) of who survived. Thus, 29 of 45 (64%) patients survived from prenatal diagnosis to discharge following the Norwood procedure. Of the 53 postnatally diagnosed patients who underwent the Norwood procedure, 42 (79%) survived. Prenatal diagnosis was not associated with improvement in survival, preoperative stability, or postoperative morbidity. By multivariate analysis, ascending aortic diameter equal to or greater than 2 mm (p = 0.01), and gestational age 36 weeks or greater (p = 0.01) independently predicted survival. Based on this, patients were stratified into groups at low risk, consisting of 69 patients, and at high risk, consisting of 19 patients. Prenatal diagnosis ...Continue Reading

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Citations

Dec 6, 2005·Clinics in Perinatology·Meryl S Cohen, Michele A Frommelt
Jan 10, 2009·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Nee Scze KhooTerry Robertson
Jun 25, 2005·The Annals of Thoracic Surgery·Clifford L CuaTimothy F Feltes
Apr 24, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·B J HollandC R Woods
Sep 14, 2006·Current Opinion in Pediatrics·Bettina F Cuneo
Aug 20, 2014·Current Opinion in Pediatrics·Stacy A S KillenAnn Kavanaugh-McHugh
Mar 5, 2016·Pediatric Cardiology·William N EvansHumberto Restrepo
Aug 20, 2018·Pediatric Cardiology·Roland W WeberEmanuela R Valsangiacomo Buechel

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