Abstract
In most cases, squamous cell carcinoma of the anus (SCCA) is treated with chemo-radiotherapy preserving sphincter function and offering good long-term survival and low recurrence rates. However, chemo-radiotherapy has several side effects: dyspareunia, impotence, fecal incontinence, pain, and skin symptoms. Small/T1 tumors, without metastatic disease, can be treated with local excision alone. We aimed to systematically review the literature regarding outcome following local excision of T1 SCCA. PubMed and Embase databases were searched for studies that investigated outcome following local excision of SCCA. Twenty-three studies were included. Twenty of the studies were retrospective, and three studies included more than 100 patients. Most of the studies were published before the 1980s. Overall there was great heterogeneity and missing data across the included studies when comparing patient demographics, resection margins, definitions on tumor location, and outcome. Overall 5-year survival was 69% (95% CI 66-72) following local excision. Overall 5-year recurrence was 37% (95% CI 30-45) following local excision. No complications were reported following local excision. The current literature on outcome following local excision of T...Continue Reading
References
Aug 1, 1978·The Australian and New Zealand Journal of Surgery·A M Cuthbertson, A H Kaye
Nov 1, 1975·Cancer·A F Cortese
Mar 11, 1976·American Journal of Surgery·G T Golden, J S Horsley
Apr 1, 1991·Diseases of the Colon and Rectum·H P LorenzW Schecter
Aug 1, 1989·The British Journal of Surgery·M P PintorR J Nicholls
Apr 1, 1988·Diseases of the Colon and Rectum·S L JensenO V Nielsen
Jan 1, 1985·American Journal of Surgery·M J GreenallJ J DeCosse
Sep 1, 1985·American Journal of Surgery·M Merlini, P Eckert
May 1, 1974·Diseases of the Colon and Rectum·N D NigroB Considine
Jul 1, 1984·Cancer·B M BomanR J Spencer
Sep 1, 1982·Scandinavian Journal of Gastroenterology·M BoheL Leandoer
May 1, 1963·Archives of Surgery·B M DILLARDH R BUTCHER
Nov 6, 2008·Annals of Surgical Oncology·K G SunesenS Laurberg
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Feb 27, 2013·Acta Oncologica·Anne Gry BentzenMarianne Grønlie Guren
Apr 13, 2013·The Lancet Oncology·Roger D JamesDavid Sebag-Montefiore
Jun 21, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Robert Glynne-JonesDirk Arnold
Mar 19, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R AranaI Etienney
Jul 29, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K G SunesenS Laurberg
Mar 26, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M Alfa-WaliM Bower
Jul 14, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kurian JosephColin Field
Oct 19, 2016·American Journal of Clinical Oncology·Ashish A DeshmukhScott B Cantor
Oct 20, 2017·JAMA Surgery·Christy Y ChaiNader N Massarweh
May 1, 1972·The Australian and New Zealand Journal of Surgery·K J HardyA M Cuthbertson
Mar 2, 2018·Acta Oncologica·Otilia LeonAnders Johnsson
Jul 15, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Al B BensonDeborah A Freedman-Cass
Apr 30, 2019·Journal of Gastrointestinal Oncology·Sakti ChakrabartiAmit Mahipal
Aug 9, 2019·Journal of Gastrointestinal Oncology·Irini YoussefDavid Schreiber
Mar 23, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Xiang GaoImran Hassan