Outcome following local excision of T1 anal cancers-a systematic review.

International Journal of Colorectal Disease
T B PedersenM F Klein

Abstract

In most cases, squamous cell carcinoma of the anus (SCCA) is treated with chemo-radiotherapy preserving sphincter function and offering good long-term survival and low recurrence rates. However, chemo-radiotherapy has several side effects: dyspareunia, impotence, fecal incontinence, pain, and skin symptoms. Small/T1 tumors, without metastatic disease, can be treated with local excision alone. We aimed to systematically review the literature regarding outcome following local excision of T1 SCCA. PubMed and Embase databases were searched for studies that investigated outcome following local excision of SCCA. Twenty-three studies were included. Twenty of the studies were retrospective, and three studies included more than 100 patients. Most of the studies were published before the 1980s. Overall there was great heterogeneity and missing data across the included studies when comparing patient demographics, resection margins, definitions on tumor location, and outcome. Overall 5-year survival was 69% (95% CI 66-72) following local excision. Overall 5-year recurrence was 37% (95% CI 30-45) following local excision. No complications were reported following local excision. The current literature on outcome following local excision of T...Continue Reading

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Citations

Jan 25, 2021·International Journal of Colorectal Disease·Gaurav TalwarCagla Eskicioglu
Apr 22, 2021·Current Opinion in Oncology·Emilio Francesco GiuntaFrancesco Sclafani

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