Outcome implications of benzodiazepine and opioid co-prescription in kidney transplant recipients.

Clinical Transplantation
Ngan N LamKrista L Lentine

Abstract

The outcomes of benzodiazepine and opioid co-prescription are not well-defined in transplant populations. We examined linked national transplant registry and pharmaceutical records to characterize benzodiazepine and opioid use in the years before and after transplant in large US cohort of kidney transplant recipients (2007-2016; N = 98 620), and associations (adjusted hazard ratio, LCL aHRUCL ) with death and graft failure. Among the cohort, 15.6% filled benzodiazepine prescriptions in the year before transplant, and 14.0% filled benzodiazepine prescriptions in the year after transplant (short-acting, 9.5%; long-acting, 3.3%; both 1.1%). Use of short-acting benzodiazepines in the year before transplant was associated with a 22% increased risk of death in the year after transplant (aHR, 1.08 1.221.38 ), while use of all classes in the year after transplant was associated with increased risk of death from >1 to 5 years (aHR: short-acting 1.29 1.391.48 ; long-acting 1.12 1.251.40 ; both 1.46 1.742.07 ). Recipients who used benzodiazepines were also more likely to fill opioid prescriptions. Recipients who filled both classes of benzodiazepine and the highest level of opioids had a 2.9-fold increased risk of death compared to recipi...Continue Reading

References

Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sara N Davison
Jun 25, 2005·Journal of the American Society of Nephrology : JASN·Steven D WeisbordGalen E Switzer
Feb 26, 2009·Postgraduate Medical Journal·E M SalisburyE A Brown
Nov 13, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Ahraaz WyneRita S Suri
Apr 7, 2011·JAMA : the Journal of the American Medical Association·Amy S B BohnertFrederic C Blow
Aug 2, 2012·JAMA : the Journal of the American Medical Association·Lewis S Nelson, Jeanmarie Perrone
May 24, 2013·JAMA : the Journal of the American Medical Association·Deborah DowellThomas A Farley
Apr 4, 2015·American Journal of Nephrology·Krista L LentineMark A Schnitzler
Mar 16, 2016·JAMA : the Journal of the American Medical Association·Deborah DowellRoger Chou
Oct 28, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Vikas R DharnidharkaKrista L Lentine
Sep 3, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K L LentineD L Segev
Nov 25, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Holly M KoncickiJane O Schell
Dec 28, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Henry B RandallKrista L Lentine
Mar 3, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K L LentineM A Schnitzler
Aug 10, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Krista L LentineMark A Schnitzler

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Citations

Apr 14, 2021·Seminars in Cardiothoracic and Vascular Anesthesia·Ryan F WangTetsuro Sakai
Apr 14, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Krista L LentineMark A Schnitzler

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